Cellular Senescence and Extracellular Vesicles Crosstalk
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cellular Aging".
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2. Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, CH-6900 Lugano (CH), Switzerland
Interests: cardioprotection; exosomes; cardiac progenitor cells; myocardial ischemia; cardiac aging
Topical Collection Information
Dear Colleagues,
Activation of cellular senescence-associated pathways affect biosynthesis of secreted small extracellular vesicles (EV) and contribute to modifying concentration, size, cargo, and function of plasma EV in aging subjects. Senescent-like EV are functionally active and might induce cellular senescence in “normal” cells, thus contributing to the accumulation of senescent cells, a mechanism that plays a major role in the development and progression of age-related pathologies. Despite this important function, how EV change in response to aging and the underlying mechanisms that contribute to these changes are poorly understood.
The Topical Collection will evaluate manuscripts addressing original research as well as review papers trying to elucidate the role of aging cells in regulating EV content, including RNAs, proteins and lipids and the active role of such component in surrounding cells. Editors will consider studies based on in vitro and in vivo models of senescence as well as approaches envisioning senolytic agents (natural or synthetic) to revert the aging process.
Dr. Lucio Barile
Dr. Edoardo Lazzarini
Collection Editors
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Keywords
- senescence
- ageing
- stress-induced senescence
- exosomes
- extracellular vesicles
