Special Issue "The Role of Inflammation in Neurodegenerative Diseases and Its Therapeutic Prospects"
Deadline for manuscript submissions: 15 October 2023 | Viewed by 11616
Interests: neurodegenerative diseases; endothelial dysfunction; inflammation; oxidative stress; drug development
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The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is currently a matter of debate. A wide range of pathologies, such as chronic infections, autoimmune and metabolic diseases, or vascular endothelial dysfunction, among others, cause sustained activation of the innate and adaptive peripheral immune systems. In addition, low-grade chronic inflammation occurs during aging even in the absence of other pathologies, which has been called "inflammaging". Peripheral inflammation is recognized as a prominent feature contributing to the disruption of the brain-blood barrier (BBB) by various pathways resulting in several CNS disease progressions. Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and Huntington’s disease all share a pervasive feature: chronic aberrant inflammation. Despite the recognized benefits of neuroinflammation in the CNS, activation of microglia in the brain contributes to neurotoxicity, oxidative stress, and synaptic and neuronal damage.
In this Special Issue, we welcome the submission of original research manuscripts, as well as review articles focusing on the possible contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases with a focus on microglia and astrocytes activation. Specifically, articles including the following topics will be welcome:
- Crosstalk between Chronic Peripheral Inflammation and microglia and astrocytes activation;
- Inflammation caused by chronic infections, autoimmune and metabolic diseases (obesity, diabetes) and hypertension and their relationship with neurodegenerative diseases;
- Gut microbiome and inflammation in neurodegeneration;
- Inflammaging and neurodegeneration;
- BBB dysfunction in neurodegenerative disorders;
- Blood or other biomarkers of neuroinflammation with respect to neurodegeneration;
- Drug development for neurodegenerative disorders based on chronic peripheral inflammation treatment.
Dr. Dolores Viña
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- peripheral inflammation
- brain-blood barrier
- neurodegenerative disorders