Vaccines, Therapies and Research Based on Synthetic mRNA
A project collection of Cells (ISSN 2073-4409). This project collection belongs to the section "Cell Methods".
Papers displayed on this page all arise from the same project. Editorial decisions were made independently of project staff and handled by the Editor-in-Chief or qualified Editorial Board members.
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Editor
Prof. Dr. Steve Pascolo
Prof. Dr. Steve Pascolo
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Guest Editor
1. Department of Dermatology, University Hospital of Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland
2. Faculty of Medicine, University of Zurich, 8091 Zurich, Switzerland
Interests: mRNA vaccine; RNA therapies; immunotherapies; cancer
Project Overview
Dear Colleagues,
The COVID-19 pandemic has highlighted the relevance of synthetic mRNA (in vitro transcribed “ivt” mRNA) for the rapid development and implementation of safe and efficacious vaccines. This success fosters further utilisation and optimisation of ivt mRNA vaccines. However, the medical potential of ivt mRNA is not restricted to vaccines but extends to “protein replacement” therapies whereby the ivt mRNA is utilised in its non-immunostimulating forms to code for therapeutic proteins. In addition, ivt mRNA that can be used for diverse methods of DNA engineering (e.g., meganucleases, TALEN, CRISPR/CAS) is being exploited both for fundamental research and clinical applications that are new avenues in the treatment of, for example, genetic diseases.
It is the goal of this Special Issue to present the potential of ivt mRNA in medicine (optimisation and utilisations of ivt mRNA) and in research.
We look forward to your contributions.
Prof. Dr. Pascolo Steve
Guest Editor
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Keywords
- synthetic mRNA
- ivt mRNA
- mRNA vaccines
- mRNA therapies
- ivt mRNA-based gene editing
Published Papers (1 paper)
2021
Open AccessReview
Vaccines against COVID-19: Priority to mRNA-Based Formulations
by
Steve Pascolo
Cited by 17 | Viewed by 4667
Abstract
As of September 2021, twenty-one anti-COVID-19 vaccines have been approved in the world. Their utilization will expedite an end to the current pandemic. Besides the usual vaccine formats that include inactivated viruses (eight approved vaccines) and protein-based vaccines (four approved vaccines), three new
[...] Read more.
As of September 2021, twenty-one anti-COVID-19 vaccines have been approved in the world. Their utilization will expedite an end to the current pandemic. Besides the usual vaccine formats that include inactivated viruses (eight approved vaccines) and protein-based vaccines (four approved vaccines), three new formats have been validated: recombinant adenovirus (six approved vaccines), DNA (one approved vaccine), and messenger RNA (mRNA, two approved vaccines). The latter was the fastest (authorized in 2020 in the EU, the USA, and Switzerland). Most Western countries have reserved or use the protein vaccines, the adenovirus vaccines, and mRNA vaccines. I describe here the different vaccine formats in the context of COVID-19, detail the three formats that are chiefly reserved or used in Europe, Canada, and the USA, and discuss why the mRNA vaccines appear to be the superior format.
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