Special Issue "HIV–Host Cell Interaction"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 2189

Special Issue Editor

Institute of Microbiology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
Interests: HIV; latency; integration; epitranscriptomics; innate immunity; single-cell
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite collective efforts in understanding HIV infection and efficient antiviral therapies, we still do not have a sterilizing cure. Novel technological advancements, e.g., in microscopy imaging and in single-cell analyses, as well as recent studies continue to uncover novel mechanisms previously ignored or allow for the revisiting of old dogmas, opening additional perspectives for novel antiviral strategies and therapeutic interventions.

With this perspective in mind, the aim of this Special Issue is to provide an overview of the current knowledge on the HIV life cycle, its multiple interactions with cellular proteins that promote or inhibit viral progression, as well as novel targets and antiviral strategies for drug development and HIV cures.   

Prof. Dr. Angela Ciuffi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV replication
  • virus–host interactions
  • innate immunity
  • restriction factors
  • productive infection
  • latency
  • antivirals
  • HIV cures

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
HIV–Host Cell Interactions
Cells 2023, 12(10), 1351; https://doi.org/10.3390/cells12101351 - 09 May 2023
Cited by 1 | Viewed by 1980
Abstract
The development of antiretroviral drugs (ARVs) was a great milestone in the management of HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells and prolonging life. However, an effective treatment has remained elusive for four decades [...] Read more.
The development of antiretroviral drugs (ARVs) was a great milestone in the management of HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells and prolonging life. However, an effective treatment has remained elusive for four decades due to the successful immune evasion mechanisms of the virus. A thorough understanding of the molecular interaction of HIV with the host cell is essential in the development of both preventive and curative therapies for HIV infection. This review highlights several inherent mechanisms of HIV that promote its survival and propagation, such as the targeting of CD4+ lymphocytes, the downregulation of MHC class I and II, antigenic variation and an envelope complex that minimizes antibody access, and how they collaboratively render the immune system unable to mount an effective response. Full article
(This article belongs to the Special Issue HIV–Host Cell Interaction)
Show Figures

Graphical abstract

Back to TopTop