New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1084

Special Issue Editors

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Guest Editor
Department of Maxillofacial Surgery, The Ludwik Rydygier Specialist Hospital, Krakow, Poland
Interests: head and neck cancer; maxillofacial surgery; prognostic biomarkers; cancer biology; immunohistochemistry
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Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Interests: epithelial-mesenchymal transition; colorectal carcinoma; precancerosis and carcinoma of the head and neck; inflammatory bowel disease; organ fibrosis
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Guest Editor
Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Wroclaw, Poland
Interests: stem cell biology; regenerative medicine; immunopathology; molecular biology; cancer stem cells biology
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Special Issue Information

Dear Colleagues, 

Head and neck cancer is a heterogenous malignancy with high mortality and increasing incidence worldwide. Late diagnosis, rapid tumour growth, poor response to radiochemotherapy and early local recurrence are still key challenges in modern treatment. Growing evidence suggests that the highly aggressive behaviour of head and neck cancer may be an effect of cancer stem cells and abnormalities in the signalling pathways associated with them. Despite recent advances in therapeutic strategies, the 5-year survival rate has remained stable in recent decades at about 50%. For this reason, further studies elucidating head and neck cancer biology are urgently required to improve the survival of patients.
We are delighted to present this Special Issue of Cells that is focused on the latest advances and future trends in the diagnosis, prognosis and treatment of head and neck cancer. This Special Issue will present original research articles as well as up-to-date review papers that present cellular and molecular mechanisms of head and neck cancer and, in particular, new specific biomarkers or potential therapy targets that may allow us to better stratify the prognosis of patients and improve their clinical outcome. We would like to encourage head and neck cancer researchers around the world to submit their manuscripts to this Special Issue.

Dr. Piotr Cierpikowski
Dr. Nina Zidar
Prof. Dr. Julia Bar
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • head and neck cancer
  • oral cancer
  • biomarker
  • prognosis
  • carcinogenesis
  • oral premalignant lesions
  • cancer stem cells
  • signaling pathways
  • molecular targeted therapy

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Published Papers (1 paper)

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19 pages, 3116 KiB  
Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells
by Hong Wan, Muy-Teck Teh, Giulia Mastroianni and Usama Sharif Ahmad
Cells 2023, 12(23), 2710; - 26 Nov 2023
Viewed by 886
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 expression. Four mRNA libraries of oral squamous carcinoma [...] Read more.
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 expression. Four mRNA libraries of oral squamous carcinoma H413 cell lines were sequenced, and 599 candidate genes exhibited differential expression between DSG3-overexpressing and matched control lines, with 12 genes highly significantly differentially expressed, including 9 upregulated and 3 downregulated. Genes with known implications in cancer, such as MMP-13, KRT84, OLFM4, GJA1, AMOT and ADAMTS1, were strongly linked to DSG3 overexpression. Gene ontology analysis indicated that the DSG3-associated candidate gene products participate in crucial cellular processes such as junction assembly, focal adhesion, extracellular matrix formation, intermediate filament organisation and keratinocyte differentiation. Validation of RNA-Seq was performed through RT-qPCR, Western blotting and immunofluorescence analyses. Furthermore, using transmission electron microscopy, we meticulously examined desmosome morphology and revealed a slightly immature desmosome structure in DSG3-overexpressing cells compared to controls. No changes in desmosome frequency and diameter were observed between the two conditions. This study underscores intricate and multifaceted alterations associated with DSG3 in oral squamous carcinoma cells, implying a potential oncogenic role of this gene in biological processes that enable cell communication, motility and survival. Full article
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