Special Issue "Understanding Retinopathy at the Neuro-Glial-Vascular Intersection: Mechanisms, and Potential Therapeutic Targets"
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 16251
Interests: vascular biology; angiogenesis; neurodegeneration; inflammation; ischemia; diabetes
Special Issues, Collections and Topics in MDPI journals
Interests: ischemic retinopathy and stroke
Interests: retinal neurodegeneration; glaucoma; ocular pharmacology; astrogliosis
Neurons, in general and specifically in the central nervous system, are highly demanding cells requiring continuous metabolic support, meticulous environmental maintenance and the intricate regulation of immune factors. Therefore, in order to maintain retinal homeostasis, the retinal blood supply is under tight regulation and surveillance by vascular, glial, neuronal, and resident immune cells. Ischemia, glial activation, inflammation, and neurodegeneration are common denominators in the development and progression of the pathogenesis observed in retinal diseases. Despite the recent advances in the treatment of retinal diseases, especially with the advent of anti-VEGF therapy and laser photocoagulation, retinal disease continues to be a major cause of blindness worldwide. Moreover, current treatments require sophisticated expertise and come with the risk of adverse outcomes that discourage ophthalmologists from tackling the diseases at earlier stages. Hence, the search for novel therapeutic modalities with better applicability, accessibility, and safety is continuing.
Advances in experimental models (in vivo, ex vivo, and in vitro) improve the understanding of the pathogenic factors behind retinal diseases and provide better insights into potential therapeutics. Despite the lack of perfect experimental models, studies using pre-clinical models help guide rational experimental design to target unanswered questions and promote the wider applicability of research findings in various pathologies sharing common cell type involvement.
This Special Issue welcomes contributions (both reviews and research articles) that advance our understanding of the specific responses of the various retinal cells to retinal injury and/or strategies to limit such damage and promote repair. Topics include, but are not limited to, human and experimental studies addressing the following retinopathies:
- Diabetic retinopathy;
- Ischemic retinopathy (retinal artery or vein occlusion);
- Retinopathy of prematurity;
- Optic neuritis and traumatic optic neuropathy.
Prof. Dr. Ruth B. Caldwell
Dr. Abdelrahman Y. Fouda
Dr. Syed A. H. Zaidi
Dr. Ammar A. Abdelrahman
Guest Editor Assistants
Manuscript Submission Information
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- neurovascular unit