Pathophysiology of Central Nervous System Tumors

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 135

Special Issue Editor


E-Mail Website
Guest Editor
Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands
Interests: pediatric neuro-oncology; neuropathology; multi-omics; immunotherapy; targeted therapy

Special Issue Information

Dear Colleagues,

The tremendous increase in knowledge of the molecular characteristics of central nervous system (CNS)  tumors over the last decade has created a fundamental change in the basic concepts and experimental practices of CNS tumors. Epigenetic profiling has allowed for classification and re-classification of CNS tumors with many ‘new’ CNS tumor entities, all with characteristics molecular profiles. This has led us to realize the complexity and heterogeneity among the distinct CNS tumor entities, necessitating in-depth profiling of these tumors in order to provide proper treatment for the distinctive CNS tumors. In order to grasp the diversity and relevance of the cell populations within each CNS tumor, it is crucial to conduct synchronized assessments that connect the genetic makeup and its epigenetic control to the expression of genes and proteins at the individual cell level. Extensive multiomic profiling (e.g. single-cell RNA sequencing, transcriptomics, proteomics) will have a strong impact on the understanding of tumor-intrinsic neuropathophysiology. Simultaneously, extrinsic microenvironmental factors, including the interplay between neoplastic cells and neurons or cells of the tumor immune micro environment (TIME), will regulate and modulate the pathophysiology of CNS tumors. More in-depth knowledge of this interplay may allow for tailored (immune) therapy.

The purpose of this Special Issue is to highlight recent findings regarding in-depth profiling of either the neoplastic compartment or the extrinsic microenvironmental  compartment of  CNS tumors, both for adult- and pediatric-type CNS tumors. The goal of this issue is to provide a broad scope that includes research papers and reviews related to in-depth (multiomic) profiling of CNS tumors, directly or indirectly affecting pathogenesis and disease.

Dr. Mariëtte E.G. Kranendonk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CNS tumor
  • pediatric
  • adult
  • molecular profiling
  • multiomics
  • microenvironment

Published Papers

This special issue is now open for submission.
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