Engineering Stem Cells for Islet Replacement Therapy

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 233

Special Issue Editors

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Guest Editor
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada
Interests: pluripotent stem cells; islet cell differentiation; beta cell replacement or regeneration; cellular heterogeneity; single cell omics; islet transplantation; graft maturation; off-target concerns
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Guest Editor
Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
Interests: insulin resistance; diabetes; lipid metabolism; glucose metabolism; disease prevention; obesity metabolic endocrinology; high fructose corn syrup; cardiovascular disease; obesity; telemedicine; telehealth; eHealth; mHealth; digital health; review; connected diabetes care; diabetes mellitus; glucose monitoring
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As the demand for effective treatments for diabetes continues to rise, stem cell-based approaches hold immense promise for providing a long-term solution to the challenges associated with islet replacement. This Special Issue aims to bring together cutting-edge research, perspectives, and reviews to foster a comprehensive understanding of the advancements, challenges, and future directions in this rapidly evolving field. This Special Issue will provide a comprehensive platform for researchers, clinicians, and policymakers to access the latest advancements and breakthroughs in the field of stem cells for islet replacement therapy. By highlighting the challenges, opportunities, and potential solutions, this collection of articles will significantly contribute to the advancement of this vital area of regenerative medicine and its translation into clinical practice. Potential topics include, but are not limited to:

  • Directed differentiation protocols to generate functional islets from different types of stem cells;
  • Bioengineering approaches to optimize the 2D or 3D microenvironment for islet replacement;
  • Genetic engineering and genome editing tools for improving safety and efficacy;
  • Biomaterials and scaffolds for encapsulation and protection of islet-like cells;
  • Preclinical and clinical studies evaluating the therapeutic potential of stem cell-derived islets;
  • Immunomodulation strategies to prevent graft rejection and improve long-term engraftment;
  • Comparative studies between and sites for islet transplantation.

We believe that by dedicating focused attention to stem cells for islet replacement therapy, we can accelerate progress in this field and ultimately improve the lives of patients living with diabetes.

Dr. Nidheesh Dadheech
Prof. Dr. Itamar Raz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • beta cell replacement therapy
  • stem cells
  • pluripotent stem cells
  • diabetes
  • biomanufacturing
  • biomaterials and encapsulation
  • gene editing
  • islet transplantation
  • immunomodulation strategies

Published Papers

There is no accepted submissions to this special issue at this moment.
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