Dear Colleagues,

The transfer of electrons between atoms is the simplest way to mobilize chemical energy between molecules. Indeed, oxidative and reductive processes represent the cell’s unavoidable path for recruiting and managing metabolic energy. Hence, the catabolic pathways through which metabolic energy is made available for biosynthetic purposes or more generally for allowing the variety of cellular functions are closely related to redox processes. Thus, molecular oxygen and/or a number of intracellular redox systems allow the replenishment of high-energy molecules on which cellular life relies. On the other hand, anabolism often proceeds via reductive steps, which are also essential to counteract the conditions of oxidative stress deriving from the oxidative environment in which cellular life normally takes place. In this regard, the redox homeostasis of cellular systems represents a goal pursued in all living organisms. Such a large network of molecular events requires rigorous metabolic control via oxidoreductases activities, in charge of catalyzing the single competing events. Oxidoreductases represent the largest and most articulated enzyme class with over 1400 entries. This is due both to the variety of redox reactions used in different organisms to meet metabolic needs and to the specificity of the enzymes involved. Thus, many different dehydrogenases targeting specific substrates and cofactors, oxidases, and peroxidases are recruited to drive metabolic reactions, to control transmembrane trafficking, and to perform an antioxidant/detoxifying action.

The aim of this Special Issue is to offer a common platform where the action of different oxidoreductases, acting on reversible or irreversible reactions, can be dissected in terms of structural determinants, catalytic properties, regulatory features, and metabolic function.

Prof. Dr. Umberto Mura
Guest Editor

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• oxidoreductases
• dehydrogenases
• pyridine redox cofactors
• flavine redox cofactors
• oxygenases
• hydroxylases
• peroxidases
• oxidative stress
• antioxidant enzymes
• glutathione
• metallothionein