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Special Issue "Friends or Foes: Innate Immune Cells and Soluble Mediators in Mucosal Inflammation"
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2444
Special Issue Editors
E-Mail Website1 Website2
Interests: asthma; autoimmunity; BTK; epigenetics; immune signaling; lymphocytes
Special Issues, Collections and Topics in MDPI journals
2. Department of Cell Biology, Erasmus MC Rotterdam PO Box 2040, NL 3000 CA Rotterdam, The Netherlands
Interests: lymphocytes,; neutrophils; chemokines; leukocyte migration; immunological memory; auto-inflammation & autoimmunity
Interests: lymphocytes; innate lymphoid cells; T cells; inflammatory bowel disease; cytotoxicity; mucosal immunology
Special Issue Information
Mucosal barrier tissues—such as the lungs and intestines—are the first contact sites for potentially harmful substances present in the external environment. These complex cellular landscapes are tasked with maintaining tissue homeostasis by tolerating harmless (self)antigens while eliminating pathogenic threats.
Optimal host protection at mucosal surfaces initially depends on dynamic cooperation between epithelial cells and dedicated innate immune cells. Epithelial cells form the first line of defense by providing a physical and biochemical barrier. Resident innate immune cells, including dendritic cells and macrophages, act as sentinels by sensing pathogen- or danger-associated signals. Following activation, they secrete an array of soluble factors, including cytokines, chemokines and growth factors, that act in concert with epithelium-derived mediators to activate innate lymphoid cells (ILCs) and recruit neutrophils and monocytes into the tissue. Instructed by the local cytokine and chemokine milieu, innate immune cells not only activate the adaptive arm to provide a specific long-lasting response, but also directly contribute to pathogen elimination and are involved in regaining tissue homeostasis after pathogen clearance.
Correct fine-tuning of mucosal immune responses is vital for health, as intrinsic defects in innate immune mechanisms feed into susceptibility to infections or malignancies, whereas excessive activation may cause chronic inflammation and tissue damage.
With this Special Issue, we wish to provide new insights into the role of innate immune cells and soluble mediators such as cytokines and chemokines in mucosal immunology in health and disease. We invite you to contribute original research articles, reviews or shorter perspective articles related to this topic.
Dr. Rudi Hendriks
Dr. Mieke Metzemaekers
Dr. Lisette Krabbendam
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- innate immunity
- mucosal immunology
- innate leukocytes