Special Issue "Neuroplasticity of Central Nervous System in Health and Disease—Series 2"

Dear Colleagues,

The need for a Second Edition of the Special Issue “Neuroplasticity of Central Nervous System in Health and Disease” demonstrates that plasticity represents a key feature of the CNS and a hot topic in the neurosciences. To date, plasticity arises from both short- and long-term adaptive synaptic changes and the “multidirectional” interactions between neural cells and their networks, extracellular matrix, and vascular system. In this context, activated glial cells, through complex mechanisms, including neuroinflammation, failure of neurovascular coupling, and metabolic/mitochondrial dysfunction, contribute to disrupting the complex neuroglial networks underlying neural homeostasis and connectivity within brain circuits. To date, this condition, called maladaptive synaptic plasticity, might represent a common primer pathogenetic mechanism for inflammatory, neurodegenerative, and psychiatric disorders. The possibility to directly modulate synaptic functions and plasticity through induction of both short- and long-term neurobiological after-effects with non-invasive brain stimulation techniques is paving the way for new therapeutic strategies in treating neuropsychiatric disorders. Unraveling the complex brain structure and function at each level, from basic mechanisms to dynamic circuitry, will allow an understanding of synaptic plasticity and higher brain functions and how their perturbations contribute to brain diseases

Dr. Giovanni Cirillo
Guest Editor

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• synaptic plasticity
• glial cells
• neuroglial homeostasis
• maladaptive plasticity
• neuropsychiatric disorders
• non-invasive brain stimulation techniques

• Neuroplasticity of Central Nervous System in Health and Disease in Cells (3 articles)