Special Issue "Aging in Neuronal Networks"
Deadline for manuscript submissions: 30 September 2023 | Viewed by 889
Interests: neurophysiology; cholinergic system; barrel cortex; somatosensory system; IGF-I; orexin; EEG; aging; diabetes; sleep
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Healthy aging is accompanied by a decline in cortical activity with an impairment in cognitive information processing. Both animal and human studies have shown that aging is associated with alterations in synaptic transmission and structural synaptic changes, as well as a consistent loss of synaptic connections. Many of the studies that have been carried out so far have focused on demonstrating that there are changes in the synaptic and intrinsic properties of neurons. However, less is known about the alterations at the neuronal network level. Healthy aging is associated with a decline in various memory abilities, and sleep disturbances are also common. These processes involve the participation of numerous areas in the nervous system that interact with each other. Therefore, studying aging as a global process that can affect some centers more than others is a subject of great scientific and social interest. These studies at the neuronal network level could develop new therapies that may improve healthy aging. This work will focus on the changes that occur in neuronal circuits during aging which would explain the deterioration that occurs during normal aging in different cognitive processes such as learning, memory, attention or the sleep–wake cycle.
Prof. Dr. Ángel Núñez
Dr. Nuria García-Magro
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- synaptic plasticity
- neuronal excitability
- intracellular signaling
- cognitive decline