Special Issue "Inflammatory Processes in Healthy and Diseased Brains"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 130
Increasing evidence has been accumulating over the past years which supports a pivotal role for inflammation in the pathogenesis of several neurological diseases, even those classically regarded as purely “neurodegenerative”. Microglia, monocytes, astrocytes, and neurons have been shown to play major roles in AD-associated inflammation and recent studies have showed that the role of both T and B lymphocytes may be important too. Inflammatory changes also occur in the brains of Parkinson's disease patients and these aspects are becoming matters of intense research. The immune response has also been involved in the pathogenesis of amyotrophic lateral sclerosis and fronto-temporal dementia.
The importance of the immune response in the pathogenesis of these diseases is highlighted by the number of molecules involved in inflammation which are associated with an increased risk of neurodegenerative disease in genome-wide association studies.
Dr. Domenico Plantone
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- immune response