Special Issue "Chromatin Remodeling Control of Neural Development and Regeneration"
Deadline for manuscript submissions: 15 October 2023 | Viewed by 719
Interests: epigenetics; neural repair; brain tumors
Recent advances have revealed that modification of the chromatin structure is an important determinant of neural cell development and function, as well as a determinant of the maintenance of brain health. Chromatin-modifying enzymes, through the regulation of DNA methylation, chromatin remodeling, and histone post-translational modifications, are critical for gene transcriptional processes to control and maintain cell-type identity and functions. Aberrant epigenetic mechanisms exerted through chromatin modifications contribute to diverse facets of neurological diseases. In addition, the pro-regenerative program is likely silenced or repressed transcriptionally in adult neural cells, including neurons and glial cells, limiting the capacity for repair after injury in the central nervous system. Here, we present recent advances with a focus on chromatin modifications for transcriptional regulation in both cellular and developmental contexts. We discuss the contribution of chromatin modifications to various pathophysiological aspects of neurological diseases and the potential implications for therapeutic approaches.
Dr. Qing Richard Lu
Dr. Jiang Wu
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- chromatin remodeling
- histone-modifying enzymes
- neurodevelopmental disorders
- neurodegenerative diseases
- neural repair