Special Issue "RNA Interference (RNAi): Mechanisms and Applications"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: 15 December 2023 | Viewed by 239

Special Issue Editor

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia
Interests: cancer biology and cancer therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

RNA interference (RNAi) is a conserved gene-regulation mechanism in all eukaryotic cells, where micro-RNA (miRNA), small interfering RNA (siRNA), and small hairpin RNA (shRNA) interact with mRNAs in a sequence-specific way and lead to the cleavage or translational blockage of the gene. Since its discovery in 1996, it has been widely used as a powerful tool for gene function studies in biology laboratories worldwide. In addition, because the blockage is sequential-specific and at the transcriptional level, RNAi-mediated gene silencing (RNAi therapy) is believed to hold great promise for effectively treating many diseases. For example, RNAi has been proven to be effective in gene therapy for viral infections, genetic disorders, and cancers.

Thanks to recent advances in drug delivery systems, especially advanced nanotechnology, siRNA delivery has seen great progress and exciting new results, bringing RNAi therapy much closer to clinical application. So far, several RNAi products have been successful on the market. In addition to RNAi therapy, another area attracting attention is the relationship between the RNAi pathway and host immune system; that is, RNAi not only involves innate immunity but also adaptive immunity. A better understanding of this relationship and combination of gene silencing with induced immunity will lead to more effective and safer therapies for cancer or other diseases.

Dr. Wenyi Gu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • RNA interference
  • gene therapy
  • gene silencing
  • miRNA /therapy
  • drug/siRNA delivery
  • RNAi and immunity
  • miRNA and immunity

Published Papers

This special issue is now open for submission.
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