Extracellular Vesicles: Biogenesis, Cargo and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 1597

Special Issue Editors


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Guest Editor
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3083, Australia
Interests: extracellular vesicles; exosomes; cancer biology; cancer cell proteomics; metastasis; bioinformatics
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Assistant Guest Editor
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia
Interests: neuroblastoma; breast cancer; extracellular vesicles; cancer signaling; Wnt; metastasis intercellular communication; EMT; proteomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Extracellular vesicles (EVs) are membranous vesicles of 30–5000 nm in size. EVs are heterogeneous and are secreted into the extracellular matrix by the cells under both physiological and pathological conditions. These EVs can be divided into three categories based on their biogenesis; exosomes, ectosomes, or shedding microvesicles and apoptotic bodies. Recent studies have identified EVs as critical players in intercellular communication. EVs carry a rich cargo of proteins, nucleic acids, lipids, and metabolites constantly mirroring the cell of origin and can potentially moderate various signaling pathways in the recipient cells. EVs have been isolated from a variety of biological fluids including saliva, blood, urine, bile, and milk. The occurrence of enriched proteins and RNA in EVs highlights the existence of specific sorting mechanisms that contribute to the selective packaging of various cargo. However, due to the lack of comprehensive functional studies regarding the molecular machinery of cargo sorting, these complex mechanisms remain poorly understood. Due to the emerging role of EVs in diseases, it is vital to understand the sorting of EV cargo to exploit EVs for drug delivery and inhibit/decrease disease progression.

This Special Issue focusses on recent findings pertaining to EV biogenesis, characterization of EV cargo, and the role of EVs in disease progression. We warmly welcome experts to submit previously unpublished original scientific research with novel findings and reviews with a comprehensive overview of EVs.

Prof. Suresh Mathivanan
Dr. Pamali Fonseka
Guest Editors

Manuscript Submission Information

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Keywords

  • exosomes
  • ectosomes
  • apoptotic bodies
  • extracellular vesicles
  • intercellular communication
  • EV biogenesis
  • EV cargo
  • drug delivery
  • EMT
  • metastasis
  • cell–cell signaling
  • biomarkers
  • proteomics
  • transcriptomics
  • EV cargo sorting
  • disease
  • neurodegenerative diseases
  • cancer
  • immunology

Published Papers

There is no accepted submissions to this special issue at this moment.
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