Regulatory T Cells and Autoimmunity

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 1741

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Center for Cancer Immunology Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Interests: inflammation
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Dear Colleagues,

The intricate balance between immune defense and self-tolerance is a fundamental pillar of our immune system. It prevents the immune system from attacking the body's tissues and controls excessive immune responses that could harm the host. This equilibrium is maintained by regulatory T cells (Tregs) and specialized CD4+ T cells that express forkhead box transcription factor (Foxp3), which perform immunosuppressive functions. Tregs are indispensable for upholding immune stability and preventing autoimmune reactions, making them vital participants in immune homeostasis and self-tolerance. A dysregulation of Tregs reduces their immunosuppressive functions, ultimately triggering the onset and progression of numerous autoimmune diseases.

The therapeutic potential of Tregs has been demonstrated in preclinical models of autoimmune diseases. However, significant scientific and clinical challenges must be addressed before Treg-based therapies can be widely implemented. It is therefore crucial to understand the function of Tregs in regulating immune responses during autoimmune diseases and reinstating self-tolerance. This is valuable for gaining deeper insights into the mechanisms behind Treg dysfunction in autoimmunity and enhancing the effectiveness of Treg-based therapies.

This Special Issue aims to highlight recent advances in the role of Tregs in autoimmune diseases. We encourage contributions that explore the cellular and molecular aspects of CD4+Foxp3+ Treg development, maintenance, and function, with a central focus on the evolving landscape of Treg-based therapeutic approaches in autoimmune disease.

Dr. Fan Pan
Guest Editor

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Keywords

  • regulatory T cells
  • immune tolerance
  • Foxp3
  • autoimmune disease (AD)
  • immunotherapy

Published Papers (1 paper)

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26 pages, 5949 KiB  
Article
Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA
by Varvara G. Blinova, Yulia A. Gladilina, Anna A. Abramova, Daria D. Eliseeva, Valentina V. Vtorushina, Anastasia N. Shishparenok and Dmitry D. Zhdanov
Cells 2024, 13(1), 77; https://doi.org/10.3390/cells13010077 - 29 Dec 2023
Cited by 1 | Viewed by 1543
Abstract
The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, the human FoxP3 gene produces four different splice variants: a full-length variant (FL) and truncated variants [...] Read more.
The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, the human FoxP3 gene produces four different splice variants: a full-length variant (FL) and truncated variants with deletions of each of exons 2 (∆2 variant) or 7 (∆7 variant) or a deletion of both exons (∆2∆7 variant). Their involvement in the biology of Tregs as well as their association with autoimmune diseases remains to be clarified. The aim of this work was to induce a single FoxP3 splice variant in human Tregs by splice switching oligonucleotides and to monitor their phenotype and proliferative and suppressive activity. We demonstrated that Tregs from peripheral blood from patients with multiple sclerosis preferentially expressed truncated splice variants, while the FL variant was the major variant in healthy donors. Tregs with induced expression of truncated FoxP3 splice variants demonstrated lower suppressive activity than those expressing FL variants. Reduced suppression was associated with the decreased expression of Treg-associated suppressive surface molecules and the production of cytokines. The deletion of exons 2 and/or 7 also reduced the cell proliferation rate. The results of this study show an association between FoxP3 splice variants and Treg function and proliferation. The modulation of Treg suppressive activity by the induction of the FoxP3 FL variant can become a promising strategy for regenerative immunotherapy. Full article
(This article belongs to the Special Issue Regulatory T Cells and Autoimmunity)
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