Immune Functions and Therapeutic Potential of B Lymphocytes in Autoimmune Disorders

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 134

Special Issue Editor


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Guest Editor
1. Graduate Institute of Biomedical Sciences, China Medical University Taichung, Taichung, Taiwan
2. Institute National de la Santé et de la Recherche Médicale (INSERM), Paris, France
Interests: immune tolerance; autoimmunity; epigenetics; B lymphocytes; innate immunity; biotherapeutics
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Special Issue Information

Dear Colleagues,

Autoimmune disorders (AID) comprise over eighty diseases and affect millions of individuals worldwide. They can target virtually any tissue in an organism and lead to a multitude of symptoms and, in severe cases, to mortality. Their causes remain under investigation, and several mechanisms have been proposed. Disease management efforts face various challenges due to the incomplete understanding of their etiologies, the complexity of genetic susceptibility, the contribution of a number of environmental factors, the variable latency between exposure to the trigger(s) and clinical manifestations, and the array of disease phenotypes. Nevertheless, treatment options for AID have made significant progress, evolving from immunosuppressive mediations to the more selective targeting of a single receptor or a specific pathway, with fewer off-target effects.

AID are characterized by loss of immune tolerance to self-antigens. While several immune cell types are aberrantly activated in AID, the B cell lineage is essential for both initiating and propagating the disease process. As a result, the broad immunotherapeutic targeting of B cells has entered the clinical arena, including specific B cell depletion. However, current approaches eradicate not only self-reactive B cells but also B cell subsets that play a protective role in immune defense. Therefore, a better understanding of B cell deregulations in AID could lead to more optimized targeted therapeutics.

This Special Issue will consist of insightful articles that assist in gaining a greater understanding of the multiple roles of B lymphocytes in the initiation and progression of autoimmune reactions, as well as the novel therapeutic approaches designed to prevent and/or to treat AID. Both original research articles and review papers will be considered.

Dr. Moncef M. Zouali
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • engineered immune cells
  • autoimmune disease
  • B lymphocyte
  • animal models
  • immune tolerance

Published Papers

This special issue is now open for submission.
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