Special Issue "Circular RNAs: Non-canonical Observations on Non-canonical RNAs"
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 48487
The existence of circular RNA research among mainstream science can be ascribed to the contemporary synergism of big data and keen attention to detail by a number of research groups worldwide. Since the re-emergence of these alternatively spliced RNA transcripts, seminal advances have been made in understanding their biogenesis, interactome, and functions in diverse fields and myriad human diseases. However, the vast majority of research outputs focus on the ability of the highly stable circRNAs to interact with and impact signaling through microRNAs. This is a likely result of seminal papers in the field ascribing a few remarkable circRNAs as “miRNA sponges”. However, the stoichiometric ratio between the (often lowly expressed) circRNA and its (commonly more abundant) target is rarely in favor of a biologically relevant and functional consequence of these interactions.
It is time for yet another revolution in circRNA research to uncover functions beyond their documented ability to bind miRNAs.
This Special Issue aims to illuminate non-canonical functions for this non-canonical family of RNA molecules. As the first of its kind in the circRNA field, this issue will be widely read and, therefore, submissions are strongly encouraged from all areas on cell biology where circRNAs are emerging as key playmakers – prokaryotic, viral, eukaryotic, animal, and plant.
Assoc. Prof. Dr. Simon Conn
Manuscript Submission Information
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- circular RNAs
- cell development
- alternative splicing