Special Issue "Cell Calcium across the Phylogenetic Tree: From Physiological Signaling to Pathogenic Mechanisms"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 10169
Interests: calcium signaling; astrocytes; calcineurin; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
The calcium ion (Ca2+) is the most versatile and the most evolutionarily conserved signaling molecule, from bacteria and algae to invertebrates and mammals. The unique repertoire of receptors, channels, pumps, transporters and proteins that are involved in creating, sensing and decoding intracellular Ca2+ signals across the phylogenetic tree has been largely exploited to understand their crucial role in human physiology and pathology. Spatio-temporal Ca2+ signals regulate virtually all cellular functions, ranging from fertilization and proliferation to exocytosis, contraction, metabolism, gene expression, and motility. Moreover, the modelling of human diseases in model species such as S. cerevisiae, C. elegans, D. melanogaster, Danio rerio, and a variety of transgenic mice allowed the elucidation of the pathogenic role of deranged Ca2+-handling machinery in human pathology. Finally, advances in molecular biology and protein chemistry led to the creation of chimeric molecular probes and organisms which made possible the detection and visualization of Ca2+ signaling processes in living plants and animals. The brightest example is the Nobel-Prize-winning green fluorescent protein from the jellyfish Aequorea victoria, and its analogues from coral Dictyostelium, which revolutionized the field of cell signaling including Ca2+.
This Special Issue is organized to provide a forum for all researchers and scholars whose activity is linked to the study of Ca2+ signaling and Ca2+-regulated processes in all organisms across the phylogenetic tree. We welcome original research articles, reviews, commentaries, opinions and experimental protocols on the physiology and pathology of Ca2+ signals, components of the Ca2+ signaling toolkit, Ca2+-regulated proteins and processes studied in the species populating the Earth. These include comparative studies and contributions regarding molecular and functional evolution of Ca2+ signaling components and Ca2+-binding proteins. We also welcome contributions which exploit the molecules from diverse species to the study of Ca2+ signaling in health and disease.
Dr. Dmitry Lim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- calcium signals
- calcium homeostasis
- calcium signaling
- calcium-binding proteins
- phylogenetic tree
- animal models
- calcium probes
- calcium reporters
- calcium in health and disease