Special Issue "Cancer Stem Cells and Resistance to Therapy"
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 78983
2. Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: identification of new genes involved in cancer, its characterization and traslation to clinic; the identification and validation of new targets for anticancer drug
Special Issues, Collections and Topics in MDPI journals
In recent years, cancer stem cells (CSCs), or cancer-initiating cells (CIC), have emerged as major drivers of chemoresistance. CSCs are a subpopulation of cancer cells that possess the same self-renewal and differentiation capacities as stem cells, thus maintaining tumor growth and the ability to regenerate a heterogeneous tumor mass. Thus, CSCs have been suggested to be responsible for metastasis and tumor growth and development. Furthermore, it has been reported that traditional chemotherapy fails to target CSCs, which could account for relapse and tumor resistance. This Special Issue will review different areas that may be involved in therapy resistance dependent on CSC populations in the tumor. There are different areas such as the subpopulation heterogeneity of CSC pools in different sections of the same tumor, between primary or metastasis or the same tumor type in different patients; the difficulty to identify properly all the CIC subpopulations in the different tumor types, including the different properties of the progenitors, and, in each case, the pathways involved and the difficulty to target them pharmacologically and how the plasticity in the different aspects of metabolism may account for these differences in resistance. Finally, the relevance of the microenvironment in the response is of great relevance in the therapeutic efficacy. Any of these topics will be considered for publication, but topics of interest are not limited to this selection. Either general studies or those focusing on specific tumors could be of great interest.
Dr. Amancio Carnero
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