Special Issue "Cytoskeletal Remodeling in Health and Disease"

Dear Colleagues,

Cytoskeleton remodeling, the dynamic process of modulating the cytoskeleton structure and organization, is essential for a variety of cellular functions, including modulation of the mechanical properties of cells, morphogenesis, cell migration, intracellular transport, cell division, gene expression, and metabolism. The regulation of the cytoskeleton is a complex process that involves a vast array of proteins, signaling pathways, and molecular motors. Despite its critical role in normal cellular function, cytoskeleton remodeling contributes to a range of diseases.

Understanding the mechanisms that trigger cytoskeletal remodeling is instrumental to understand the pathophysiology of numerous musculoskeletal, cardiovascular, immunological, and neurological disorders. Dysregulation of the cytoskeleton facilitates migration, invasion, and angiogenesis characteristic of cancer metastasis. The cytoskeleton remodeling machinery is also a target that pathogens manipulate to facilitate their own spread. Exciting recent advances have identified several new proteins and pathways involved in cytoskeletal regulation, and this knowledge will be key to developing new treatments for many diseases.

This Special Issue of Cells aims to collect the newest advances in the field of cytoskeletal remodeling, with an emphasis on studies that provide insight into molecular pathogenesis and potential therapeutic interventions of disorders with a strong cytoskeletal component. Studies on microfilament-, microtubule- and intermediate filament-associated proteins and on components involved in the organization of their remodeling are welcome.

Prof. Dr. Annette Müller-Taubenberger
Dr. Francisco Rivero
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• actin cytoskeleton
• cellular mechanics
• cancer
• cytoskeletal proteins
• immunity