Special Issue "Heterochromatin and Tumorigenesis II"
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 3385
Interests: chromatin; heterochromatin; cancer; HP1; senescence; transcriptional regulation; retrotransposons
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Heterochromatin, the “dark side” of the genome, has long been considered an inert storage site for useless DNA sequences; however, there is increasing evidence that this chromatin compartment is essential for many nuclear functions, including chromosome segregation, regulation of gene expression and of DNA replication, and repair. Heterochromatin, which is mainly composed of repetitive sequences including retrotransposons, is characterized by a high level of compaction, an enrichment of the histone mark H3K9me3 and of the chromatin associated proteins HP1 (Heterochromatin Protein 1), and an extremely limited level of transcriptional activity. Many studies have shown that changing the equilibrium of the different heterochromatin components has devastating consequences in particular in the development of cancers. Several lines of evidence support the view that heterochromatin could prevent tumor development by promoting cellular senescence and by silencing retrotransposon activity. A better understanding of how heterochromatin is acting in regulating tumor development is an exciting and particularly active field of research.
This Special Issue aims to summarize the current knowledge regarding the role of heterochromatin in cancer development and how targeting components essential for its establishment and/or maintenance could lead to therapeutic breakthroughs for cancer treatment.
Dr. Florence Cammas
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