Special Issue "Blood–Brain Barrier: From Physiology to Disease and Back"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 8958
Interests: blood–brain barrier permeability and its modulation by chemical, mechanical and physical stimuli; regenerative medicine for blood–brain barriers in neurological disorders
The blood–brain barrier (BBB) is the interface between the central nervous system (CNS) and the cerebral blood circulation. It is a dynamic barrier essential for maintaining the microenvironment of the brain. Compromised BBBs have been found in various neurological disorders including schizophrenia, autism, Alzheimer’s disease, and brain tumors, to name a few. Recent advances in directing human-induced pluripotent stem cells (hiPSCs) to differentiate and generate patient-specific BBBs provide an exciting opportunity to investigate disease mechanisms responsible for these compromised BBBs. The biomimetic BBBs derived from hiSPCs not only enable the cost-effective development of systemic drug delivery methods but also drug screening targeting the neurovascular coupling for these neurological disorders. This Special Issue thus aims to collect contributions on topics including 1) the development and characterization of the BBB from primary and hiPSC-derived cells, as well as cell lines in health and disease; 2) the investigation of molecular and cellular mechanisms for compromised BBBs in neurological disorders; 3) the development of methods for drug delivery across the BBB; 4) drug screening utilizing the developed BBBs for the treatment of neurological disorders; and 5) the investigation of immune- and tumor-cell adhesion to and transmigration across the BBB. Although original contributions are preferred, focused review articles are also welcome.
Dr. Bingmei Fu
Manuscript Submission Information
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- human-induced pluripotent stem-cell-derived blood–brain barrier
- molecular structure of blood–brain barrier
- blood–brain barrier permeability
- modulation of blood–brain barrier
- drug delivery via blood–brain barrier
- blood–brain barriers on-a-chip
- biomimetic blood–brain barriers for neurological disorders
- adhesion and transmigration across the blood–brain barrier
- neurovascular coupling
- regenerative medicine