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Special Issue "Biomarkers of Alzheimer’s Disease: New Insights"
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 15809
Special Issue Editor
Interests: neuropathology; biomarkers of neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Impaired cognitive function is a hallmark of Alzheimer’s disease (AD), and often one of the first symptoms. However, changes in cognitive function develop slowly over time and patients are diagnosed at an advanced stage of molecular pathology. The failure to diagnose AD, the most common form of dementia in the elderly, at an early stage of molecular pathology is considered to be the major reason why causative treatments have failed in clinical trials. Molecular biomarkers that could detect individuals at risk for developing AD and allow for timely intervention remain highly desirable. Cortical measurements of amyloid-beta and tau depositions via magnetic resonance imaging (MRI) and positron emission tomography (PET) are expensive and thus not accessible on the scale needed for a public health challenge such as AD. Large epidemiological studies provide a sufficient number of subjects to develop a robust classifier enabling the correlation of cognitive status in densely phenotyped individuals with molecular signatures obtained via systematic biobanking using reliable standard operating procedures. To that end, plasma P-tau217 levels in multiple international cohorts distinguished AD from other neurodegenerative diseases. Because the National Institute of Aging—Alzheimer’s Association research framework aims to define AD biologically, it also seeks to expand AD biomarkers according to the scientific progress in the field of AD pathogenesis.
Prof. Dr. Ivana Delalle
Manuscript Submission Information
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- plasma AD biomarkers
- AD pathogenesis biomarkers
- biomarkers of cognitive decline
- biomarkers of neurodegeneration
- epigenetic dysregulation
- AD-risk genetic variants