New Discoveries in Dermatopathology: From Molecular Mechanisms to Therapeutic Opportunities

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2093

Special Issue Editors


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Guest Editor
1. UOC Dermatologia, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy
Interests: cutaneous lymphomas; dermatopathology; clinical research; skin pigmentation disorders

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Guest Editor
1. Dermatology Clinic, Department of Medical Sciences, University of Turin, 10124 Turin, Italy
2. Dermatology Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
3. Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy
Interests: cutaneous oncology; dermatopathology; clinical research; biological drugs; inflammatory disorders

Special Issue Information

Dear Colleagues,

Dermatopathology plays a crucial role in dermatological care by helping dermatologists and other healthcare providers make accurate diagnoses and develop appropriate treatment plans for patients with skin diseases. It contributes to the understanding of the underlying mechanisms of skin disorders and guides the development of new therapies and interventions. The field of dermatopathology encompasses a wide range of skin disorders, including infectious conditions such as fungal or viral infections, inflammatory skin diseases such as eczema and psoriasis, and various types of skin cancer.

This Special Issue will examine the molecular mechanisms of skin diseases that are crucial for identifying therapeutic targets and developing effective treatments. New discoveries in dermatopathology involving new molecular diagnostics, advanced imaging techniques and the integration of digital pathology and artificial intelligence on experimental cytology will be highlighted.

Dr. Silvia Alberti-Violetti
Dr. Gianluca Avallone
Guest Editors

Manuscript Submission Information

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Keywords

  • dermatopathology
  • target therapy
  • molecular mechanism

Published Papers (2 papers)

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Research

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13 pages, 3793 KiB  
Article
Differential Upregulation of Th1/Th17-Associated Proteins and PD-L1 in Granulomatous Mycosis Fungoides
by Mario L. Marques-Piubelli, Jesus Navarrete, Debora A. Ledesma, Courtney W. Hudgens, Rossana N. Lazcano, Ali Alani, Auris Huen, Madeleine Duvic, Priyadharsini Nagarajan, Phyu P. Aung, Ignacio I. Wistuba, Jonathan L. Curry, Roberto N. Miranda and Carlos A. Torres-Cabala
Cells 2024, 13(5), 419; https://doi.org/10.3390/cells13050419 - 27 Feb 2024
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Abstract
Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The upregulation of the T helper (Th) axis, [...] Read more.
Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The upregulation of the T helper (Th) axis, especially Th17, plays an important role in the pathogenesis of several inflammatory/infectious granulomatous cutaneous diseases, but its role in GMF is still not elucidated to date. In this study, we evaluated the immunohistochemical expression of Th1 (Tbet), Th2 (GATA-3), Th17 (RORγT), T regulatory (Foxp3), and immune checkpoint (IC) (PD-1 and PD-L1) markers in a cohort of patients with GMF and MF with large cell transformation (MFLCT). Skin biopsies from 49 patients (28 GMF and 21 MFLCT) were studied. Patients with GMF were associated with early clinical stage (p = 0.036) and lower levels of lactate dehydrogenase (p = 0.042). An increased percentage of cells positive for Tbet (p = 0.017), RORγT (p = 0.001), and PD-L1 (p = 0.011) was also observed among the GMF specimens, while a stronger PD-1 intensity was detected in cases of MFLCT. In this cohort, LCT, RORγT < 10%, Foxp3 < 10%, age, and advanced stage were associated with worse overall survival (OS) in univariate analysis. GMF demonstrated Th1 (cellular response) and Th17 (autoimmunity) phenotype, seen in early MF and granulomatous processes, respectively, which may be related to the histopathological appearance and biological behavior of GMF. Further studies involving larger series of cases and more sensitive techniques are warranted. Full article
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Review

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35 pages, 836 KiB  
Review
The Role of Cytokines in Cutaneous T Cell Lymphoma: A Focus on the State of the Art and Possible Therapeutic Targets
by Alba Guglielmo, Corrado Zengarini, Claudio Agostinelli, Giovanna Motta, Elena Sabattini and Alessandro Pileri
Cells 2024, 13(7), 584; https://doi.org/10.3390/cells13070584 - 28 Mar 2024
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Abstract
Cutaneous T cell lymphomas (CTCLs), encompassing mycosis fungoides (MF) and Sézary syndrome (SS), present a complex landscape influenced by cytokines and cellular responses. In this work, the intricate relationship between these inflammatory proteins and disease pathogenesis is examined, focusing on what is known [...] Read more.
Cutaneous T cell lymphomas (CTCLs), encompassing mycosis fungoides (MF) and Sézary syndrome (SS), present a complex landscape influenced by cytokines and cellular responses. In this work, the intricate relationship between these inflammatory proteins and disease pathogenesis is examined, focusing on what is known at the clinical and therapeutic levels regarding the most well-known inflammatory mediators. An in-depth look is given to their possible alterations caused by novel immunomodulatory drugs and how they may alter disease progression. From this narrative review of the actual scientific landscape, Interferon-gamma (IFN-γ) emerges as a central player, demonstrating a dual role in both promoting and inhibiting cancer immunity, but the work navigates through all the major interleukins known in inflammatory environments. Immunotherapeutic perspectives are elucidated, highlighting the crucial role of the cutaneous microenvironment in shaping dysfunctional cell trafficking, antitumor immunity, and angiogenesis in MF, showcasing advancements in understanding and targeting the immune phenotype in CTCL. In summary, this manuscript aims to comprehensively explore the multifaceted aspects of CTCL, from the immunopathogenesis and cytokine dynamics centred around TNF-α and IFN-γ to evolving therapeutic modalities. Including all the major known and studied cytokines in this analysis broadens our understanding of the intricate interplay influencing CTCL, paving the way for improved management of this complex lymphoma. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: RiboScreenTechnology Delivers Small Molecules for Targeted Repair of PTC Mutations in Rare Disease Junctional Epidermolysis Bullosa
Authors: Hannelore Breitenbach Breitenbach; Johann Bauer; Gazmend Temaj; et al
Affiliation: Universität Salzburg, Salzburg, Austria

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