Special Issue "DNA Damage and DNA Repair: What’s New in Biology and Cancer Therapeutics?"
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2609
Interests: DNA repair; synthetic lethality; precision oncology; breast cancer; ovarian cancer
Special Issues, Collections and Topics in MDPI journals
DNA damage signaling response and repair (DDR) is a critical defense mechanism against genomic instability. A large body of evidence suggests that impaired DNA repair capacity promotes cancer development. Interestingly, upregulation of DDR can lead to chemotherapy and/or radiotherapy resistance. Recent advances in DNA repair have led to several translational investigations, resulting in clinically viable precision oncology strategies through the use of synthetic lethality, such as the use of PARP inhibitors in breast, ovarian, pancreatic and prostate cancers. Whilst the clinical use of PARP inhibitors has expanded our knowledge on the topic, it is clear that the emergence of resistance is a considerable clinical problem. Therefore, the search for additional DDR-directed drug targets and novel synthetic lethality approaches is an area of recent research.
The Special Issue will focus on our current understanding of DNA repair pathways in humans and their exploitation for precision oncology therapeutics in cancer.
Prof. Dr. Srinivasan Madhusudan
Manuscript Submission Information
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- DNA repair pathways
- synthetic lethality
- precision oncology