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Mechanisms of Regulatory T Cell, B Cell, and Myeloid Suppressor...
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Mechanisms of Regulatory T Cell, B Cell, and Myeloid Suppressor Cell Activity

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 2058

Special Issue Editors

Dr. Gopal Murugaiyan

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Guest Editor
Department of Neurology, Harvard Medical School, Boston, MA, USA
Interests: autoimmunity; neuroinflammation; cancer; inflammation; T cells; myeloid cells; microRNA; non-coding RNA
Dr. Sophie Hillion

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Guest Editor
Lymphocyte B et Auto Immunité (LBAI), Brest, France
Interests: autoimmunity; immunology; cytokines
Prof. Dr. Yong Zhao

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Guest Editor
State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Beijing 100101, China
Interests: immunology; transplantation immunology; immune tolerance; innate immune cells

Special Issue Information

Dear Colleagues,

The elegant control of appropriate immune homeostasis and immune response in physiological and pathological conditions is important and significant. Among many immune regulatory mechanisms, regulatory immune cells such as regulatory T cells, regulatory B cells, and myeloid suppressor cells play critical roles in these processes. The abnormal activity of these regulatory cells is involved in many human diseases, such as cancers, autoimmune diseases, ageing and degenerative diseases, and the graft rejection process. A deep understanding of the immunobiology of these cells would help us to uncover the relevant pathophysiological processes of relevant diseases and identify novel therapeutic approaches.

This Special Issue will cover the basic and clinical aspects of regulatory T cells, regulatory B cells, and myeloid suppressor cells, including but not limited to the identification of new subpopulations; methods and biomarkers to isolate and maintain these cells ex vivo; the regulation of extracellular and intracellular molecules in cell differentiation and biological functions; the role of these cells in diseases, ageing and graft rejection; drug screening for these cells; the bioengineering of these cells; and the application of these cells in pre-clinical and clinical settings.

In this Special Issue of Cells we invite your contributions, in the form of original research articles or reviews, on all aspects related to recent advances in the fields of T cells, B cells, and myeloid suppressor cells.

Dr. Gopal Murugaiyan
Dr. Sophie Hillion
Prof. Dr. Yong Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regulatory T cell
  • regulatory B cell
  • myeloid suppressor cells
  • immune regulation
  • immune tolerance
  • immune disease
  • immune cell therapy

Published Papers (2 papers)

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Research

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16 pages, 2279 KiB  
Article
Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients
by Irene T. Schrijver, Jacobus Herderschee, Charlotte Théroude, Antonios Kritikos, Guus Leijte, Didier Le Roy, Maelick Brochut, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Benoit Guery, Matthijs Kox, Peter Pickkers, Thierry Calandra and Thierry Roger
Cells 2024, 13(4), 314; https://doi.org/10.3390/cells13040314 - 08 Feb 2024
Viewed by 689
Abstract
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the development of infectious diseases, but little is known about their potential predictive [...] Read more.
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the development of infectious diseases, but little is known about their potential predictive value in critically ill patients. Here, we used unsupervised flow cytometry analyses to quantify MDSC-like cells in healthy subjects challenged with endotoxin and in critically ill patients admitted to intensive care units and at risk of developing infections. Cells phenotypically similar to PMN-MDSCs and M-MDSCs increased after endotoxin challenge. Similar cells were elevated in patients at ICU admission and normalized at ICU discharge. A subpopulation of M-MDSC-like cells expressing intermediate levels of CD15 (CD15int M-MDSCs) was associated with overall mortality (p = 0.02). Interestingly, the high abundance of PMN-MDSCs and CD15int M-MDSCs was a good predictor of mortality (p = 0.0046 and 0.014), with area under the ROC curve for mortality of 0.70 (95% CI = 0.4–1.0) and 0.86 (0.62–1.0), respectively. Overall, our observations support the idea that MDSCs represent biomarkers for sepsis and that flow cytometry monitoring of MDSCs may be used to risk-stratify ICU patients for targeted therapy. Full article
(This article belongs to the Special Issue Mechanisms of Regulatory T Cell, B Cell, and Myeloid Suppressor Cell Activity)
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Review

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14 pages, 1030 KiB  
Review
Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation
by Flavia Carriero, Valentina Rubino, Stefania Leone, Rosangela Montanaro, Vincenzo Brancaleone, Giuseppina Ruggiero and Giuseppe Terrazzano
Cells 2023, 12(24), 2841; https://doi.org/10.3390/cells12242841 - 15 Dec 2023
Cited by 1 | Viewed by 981
Abstract
The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of [...] Read more.
The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of autoimmunity. The knowledge of all the mechanisms involved in immune regulation is not yet definitive, and, probably, the overall picture is much broader than what has been described in the scientific literature so far. Given the plasticity of the immune system and the diversity of organisms, it is highly probable that numerous other cells and molecules are still to be ascribed to the immune regulation process. Here, we report a general overview of how immune activation and regulation interact, based on the involvement of molecules and cells specifically dedicated to these processes. In addition, we discuss the role of TR3-56 lymphocytes as a new cellular candidate in the immune regulation landscape. Full article
(This article belongs to the Special Issue Mechanisms of Regulatory T Cell, B Cell, and Myeloid Suppressor Cell Activity)
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