Special Issue "Hypoxic-Ischemic Brain Injury: From Molecular Mechanisms to Therapeutic Opportunities"
Deadline for manuscript submissions: 15 November 2023 | Viewed by 1930
Interests: neuroscience; hypoxia; neonatal; neonatal encephalopathy; hypoxic-ischaemic encephalopathy; microRNA
Special Issues, Collections and Topics in MDPI journals
Neonatal brain damage or neonatal encephalopathy is mainly caused by hypoxia-ischemia and is a major cause of concern in neonatal units. The prognosis of infants suffering from neonatal brain damage is particularly poor, accounting for 1 million neonatal deaths every year worldwide, and survivors will develop neurological conditions. Both diagnosis and treatment, however, remain a clinical challenge with current therapeutics, being effective only in a subgroup of patients and diagnostic/prognostic methods are either inaccurate or possibly too late for an effective treatment. Since the first preclinical model developed by Rice-Vannuci in rats, new preclinical models have been developed in pigs, sheets, and mice, to mimic the pathology of neonatal encephalopathy in infants. Emerging evidence from these pre-clinical models has started to elucidate the mechanism underlying neonatal brain damage, including oxidative stress, hyperexcitability, and neuroinflammation, which will guide novel therapies and diagnostic tools. This Special Issue will compile the latest results on hypoxia-ischemia encephalopathy.
Dr. Eva María Jiménez-Mateos
Manuscript Submission Information
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The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: FOXO transcription factors and their role in ischemic brain injury
Authors: Hongmin Wang, Xiaoping Li, and Christa Huber
Affiliation: Division of Basic Biomedical Sciences and Center for Brain and Behavior Research, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA