Special Issue "Alcohol and Neuroimmunology"
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 9821
Interests: neuroimmune actions on the brain; alcohol/neuroimmune interactions; synaptic transmission; neurophysiology; calcium imaging
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Alcohol has been in use as a recreational drug for centuries, with the downside that it has negative impacts on body function, results in problematic behavior, and is addictive. There is considerable interest in the mechanisms underlying these effects of alcohol, particularly with respect to the actions of alcohol on the brain, which plays a central role the problematic behavior caused by excess alcohol use and in the development of alcohol use disorders, a widespread disease with limited treatment strategies.
Considerable research has been directed at an understanding of the interactions of alcohol with the neuronal system of the brain. However, emerging research indicates that glial cells (e.g., astrocytes and microglia) also play an important role in the actions of alcohol on the brain. Glial cells function as an innate immune system of the brain, referred to as the neuroimmune system, and produce signaling factors (e.g., cytokines) that serve as important regulators of brain function, both under physiological and pathological conditions. It is now known that alcohol interactions with this neuroimmune system play a key role in many effects of alcohol on the brain.
Although our understanding of the neuroimmune system and its interactions with alcohol are still rather limited, considerable progress has been made. This Special Issue focuses on this emerging area of research and studies that are providing critical insight into alcohol–neuroimmune interactions, potential therapeutic targets, and potential treatment strategies.
Prof. Dr. Donna Gruol
Manuscript Submission Information
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- gene regulation
- signal transduction
- alcohol use disorders