Metabolic Regulation of Hematopoietic Stem Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 1277

Special Issue Editor

Division of Hematology and Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Interests: hematopoietic stem cells

Special Issue Information

Dear Colleagues,

Hematopoietic stem cells (HSCs) are a rare population of cells residing in the bone marrow microenvironment, where they preserve the capacity to self-renew and regenerate the whole hematopoietic system during their prolonged lifespan by balancing long-term HSC survival with a demand-adapted response to stress. The decisions to self-renew or to commit to differentiation are critical to generating sufficient numbers of both HSCs and progenies while preventing HSC exhaustion. The transition from quiescence to activation is accompanied by major metabolic and mitochondrial changes that are important for cell cycle entry for balanced decisions between self-renewal and differentiation.

Cellular metabolism is a key regulator of HSC maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. Dysregulated energy metabolism is one possible mechanism underlying HSC defects in various hematological diseases, including bone marrow failure syndromes and leukemia.

This Special Issue will examine the metabolic regulation of HSCs, metabolic changes upon aging or damage, diet-derived metabolites, and novel models to investigate metabolic alterations under physiological or disease conditions.

Dr. Wei Du
Guest Editor

Manuscript Submission Information

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Keywords

  • hematopoietic stem cells
  • metabolic regulation
  • mitochondrial function
  • self-renewal and differentiation
  • quiescence
  • energy metabolism
  • HSC exhaustion
  • aging
  • bm niche
  • leukemia stem cells (LSCs)

Published Papers (1 paper)

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Review

16 pages, 2294 KiB  
Review
Crosstalk between DNA Damage Repair and Metabolic Regulation in Hematopoietic Stem Cells
by Jian Xu, Peiwen Fei, Dennis W. Simon, Michael J. Morowitz, Parinda A. Mehta and Wei Du
Cells 2024, 13(9), 733; https://doi.org/10.3390/cells13090733 - 24 Apr 2024
Viewed by 828
Abstract
Self-renewal and differentiation are two characteristics of hematopoietic stem cells (HSCs). Under steady physiological conditions, most primitive HSCs remain quiescent in the bone marrow (BM). They respond to different stimuli to refresh the blood system. The transition from quiescence to activation is accompanied [...] Read more.
Self-renewal and differentiation are two characteristics of hematopoietic stem cells (HSCs). Under steady physiological conditions, most primitive HSCs remain quiescent in the bone marrow (BM). They respond to different stimuli to refresh the blood system. The transition from quiescence to activation is accompanied by major changes in metabolism, a fundamental cellular process in living organisms that produces or consumes energy. Cellular metabolism is now considered to be a key regulator of HSC maintenance. Interestingly, HSCs possess a distinct metabolic profile with a preference for glycolysis rather than oxidative phosphorylation (OXPHOS) for energy production. Byproducts from the cellular metabolism can also damage DNA. To counteract such insults, mammalian cells have evolved a complex and efficient DNA damage repair (DDR) system to eliminate various DNA lesions and guard genomic stability. Given the enormous regenerative potential coupled with the lifetime persistence of HSCs, tight control of HSC genome stability is essential. The intersection of DDR and the HSC metabolism has recently emerged as an area of intense research interest, unraveling the profound connections between genomic stability and cellular energetics. In this brief review, we delve into the interplay between DDR deficiency and the metabolic reprogramming of HSCs, shedding light on the dynamic relationship that governs the fate and functionality of these remarkable stem cells. Understanding the crosstalk between DDR and the cellular metabolism will open a new avenue of research designed to target these interacting pathways for improving HSC function and treating hematologic disorders. Full article
(This article belongs to the Special Issue Metabolic Regulation of Hematopoietic Stem Cells)
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