The Role of Cilia in Health and Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1413
Interests: identification of new ciliary genes/components/proteins; deciphering the molecular structure of human motile cilia; genetic and molecular diagnosis of motile ciliopathies; the role of outer dynein arm docking complex in primary ciliary dyskinesia
Cilia, hair like tiny organelles present on almost every cell type of the human body, have different important functions in the maintenance of human body health and organization. Primary cilia are known for their sensory roles in development, proliferation, differentiation and cell survival; whereas motile cilia/flagella are implicated in preserving a functional airway clearance, in maintaining an appropriate cerebrospinal fluid flow, in assuring a correct left-right body asymmetry as well as male and female reproductive function. Diseases resulting from aberrant ciliary function and/or motility caused by genetic mutations in ciliary genes are known as ciliopathies. Primary Ciliary Dyskinesia (PCD) is a motile ciliopathy comprising defects in the respiratory, reproductive, central nervous and embryonic nodal systems. Due to the large spectrum of anomalies in multiple organ systems, PCD and other motile ciliopathies have to be thoroughly investigated. The identification of motile ciliopathy-associated genes is also of great importance for future possible gene therapy.
This special Issue will discuss the role of motile cilia in the human health and its pathophysiological conditions. We encourage you to contribute to this Special Issue of Cells and submit a research article, a review article, or a perspective and opinion article that are dedicated to motile cilia and their role in human health and diseases. Articles on therapeutics addressing cilia function are also encouraged.
Dr. Rim Hjeij
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- motile cilia
- motile ciliopathy
- Primary ciliary dyskinesia
- genetic screening
- laterality defects
- gene therapy