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Novel Insights into Molecular Mechanisms of Iron-Related Skin Damage and...
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Novel Insights into Molecular Mechanisms of Iron-Related Skin Damage and Disorders

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 5734

Special Issue Editors

Prof. Dr. Charareh Pourzand

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Guest Editor
Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UK
Interests: skin photoprotection; skin ironome; iron chelation therapy; photodynamic therapy of skin disorders; oxidative stress; iron sensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jun Lu

E-Mail Website
Guest Editor
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education (Southwest University), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Interests: drugs based on targeting the regulation of thiol redox system; novel biopharmaceutical technology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mingxing Lei

E-Mail Website
Guest Editor
National Innovation and Attracting Talents "111" Base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
Interests: skin organoid formation; stem cells; wound healing; dermatology; hair follicles; regenerative medicine.
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julia Li Zhong

E-Mail Website
Guest Editor
National Innovation and Attracting Talents "111" Base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
Interests: skin photoaging; autophagy; dermatology; photobiology; photomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This issue will look at the interplay between iron and oxidative stress in skin pathologies as well as skin damage due to exposure to environmental exposomes, notably sunlight. At cellular level, the phenomenon of iron-mediated cell death (ferroptosis) has also been linked to evasion or initiation and promotion of various pathologies. In all these cases, the use of iron chelators or compounds with iron-binding activity in conjunction with antioxidants appears to be beneficial as a preventive or therapeutic approach against iron-mediated oxidative damage and pathologies. There is now a clear need to understand these phenomena within the context of sunlight-mediated disruption of iron and redox homeostasis and initiation and promotion of skin inflammatory and hyperproliferative disorders. This specific issue will therefore welcome research articles and reviews discussing and reporting on basic skin research as well as preclinical and clinical dermatology-based studies within the context of iron, oxidative stress, and pathologies.

Prof. Dr. Charareh Pourzand
Prof. Dr. Jun Lu
Prof. Dr. Mingxing Lei
Prof. Dr. Julia Li Zhong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • iron
  • reactive oxygen species
  • skin
  • exposomes
  • sun damage
  • sun protection
  • dermatology
  • skin disorders
  • skin cancer
  • skin inflammatory disorders

Published Papers (1 paper)

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Review

17 pages, 1443 KiB  
Review
The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications
by Wei-Ling Chang and Chi-Hsiang Ko
Cells 2023, 12(6), 936; https://doi.org/10.3390/cells12060936 - 19 Mar 2023
Cited by 16 | Viewed by 5205
Abstract
Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing melanocytes which are attacked by immune cells. Oxidative stress is considered to play a crucial role in activating consequent autoimmune responses related to vitiligo. Melanin synthesis by melanocytes is the main intracellular stressor, [...] Read more.
Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing melanocytes which are attacked by immune cells. Oxidative stress is considered to play a crucial role in activating consequent autoimmune responses related to vitiligo. Melanin synthesis by melanocytes is the main intracellular stressor, producing reactive oxygen species (ROS). Under normal physiological conditions, the antioxidative nuclear factor erythroid 2-related factor 2 (Nrf2) pathway functions as a crucial mediator for cells to resist oxidative stress. In pathological situations, such as with antioxidant defects or under inflammation, ROS accumulate and cause cell damage. Herein, we summarize events at the cellular level under excessive ROS in vitiligo and highlight exposure to melanocyte-specific antigens that trigger immune responses. Such responses lead to functional impairment and the death of melanocytes, which sequentially increase melanocyte cytotoxicity through both innate and adaptive immunity. This report provides new perspectives and advances our understanding of interrelationships between oxidative stress and autoimmunity in the pathogenesis of vitiligo. We describe progress with targeted antioxidant therapy, with the aim of providing potential therapeutic approaches. Full article
(This article belongs to the Special Issue Novel Insights into Molecular Mechanisms of Iron-Related Skin Damage and Disorders)
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