Human Placenta and Trophoblast Cells in Pregnancy Development

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Reproductive Cells and Development".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1403

Special Issue Editor


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Guest Editor
Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA
Interests: placental development; trophoblast functioning; obstetric complications

Special Issue Information

Dear Colleagues,

Maternal–fetal interactions mediated by the placenta are critical to fetal development and overall positive outcomes during pregnancy. During gestation, the placenta mediates the interface between mother and fetus, regulating processes such as gas exchange, nutrition availability, and waste removal. The first differentiation event during placental development is the formation of trophoblast—specialized epithelial cells that form a physical connection between the embryo and the uterus. Aberrant trophoblast functioning is associated with placental deficiencies and clinical obstetric pathologies.

This Special Issue will examine the direct correlation between placenta and their trophoblast cells functioning in the development of normal and complicated pregnancies.

Dr. Juan Arroyo
Guest Editor

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Keywords

  • placenta
  • trophoblast
  • pregnancy

Published Papers (1 paper)

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Research

12 pages, 1823 KiB  
Article
An Examination of the Effect of Aspirin and Salicylic Acid on Soluble Fms-like Tyrosine Kinase-1 Release from Human Placental Trophoblasts
by Jiawu Zhao, Rui Duan, Jinghui Sun, Rebecca P. Chow, Timothy J. Lyons and Jeremy Y. Yu
Cells 2024, 13(2), 113; https://doi.org/10.3390/cells13020113 - 6 Jan 2024
Cited by 1 | Viewed by 1060
Abstract
Low-dose aspirin (LDA) is efficacious in preventing preeclampsia, but its mechanism of action is unclear. Conflicting evidence suggests that it may inhibit placental trophoblast release of soluble fms-like tyrosine kinase-1 (sFlt1), a key mediator of preeclampsia. We examined whether, and at what concentrations, [...] Read more.
Low-dose aspirin (LDA) is efficacious in preventing preeclampsia, but its mechanism of action is unclear. Conflicting evidence suggests that it may inhibit placental trophoblast release of soluble fms-like tyrosine kinase-1 (sFlt1), a key mediator of preeclampsia. We examined whether, and at what concentrations, aspirin and its principal metabolite, salicylic acid, modulate sFlt1 release and/or expression in trophoblasts. Human trophoblast lines BeWo and HTR-8/SVneo were cultured; BeWo cells were also treated with 1% oxygen vs. normoxia to mimic hypoxia in preeclamptic placentas. Cells were treated with aspirin or salicylic acid vs. vehicle for 24 h at concentrations relevant to LDA and at higher concentrations. Protein concentrations (ELISA) and mRNA expression (RT-PCR) of sFlt1 were determined. Under normoxia, LDA-relevant concentrations of aspirin (10–50 µmol/L) or salicylic acid (20–100 µmol/L) had no significant effect on sFlt1 protein release or mRNA expression in BeWo cells. However, inhibition was observed at higher concentrations (1 mmol/L for aspirin and ≥200 μmol/L for salicylic acid). Hypoxia enhanced sFlt1 protein release and mRNA expression in BeWo cells, but these responses were not significantly affected by either aspirin or salicylic acid at LDA concentrations. Similarly, neither drug altered sFlt1 protein secretion or mRNA expression in normoxic HTR-8/SVneo cells at LDA concentrations. We suggest that direct modulation of trophoblast release or expression of sFlt1 is unlikely to be a mechanism underlying the clinical efficacy of LDA in preeclampsia. Full article
(This article belongs to the Special Issue Human Placenta and Trophoblast Cells in Pregnancy Development)
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