Special Issue "Injury, Neurodegeneration, and Regeneration of Retinal Ganglion Cells"
Deadline for manuscript submissions: 30 September 2023 | Viewed by 1913
Interests: RGC death and protection; retinal circuitry development; activity-dependent synaptic plasticity; retinal ganglion cells
Interests: retinal development with a focus on the roles of transcription factors in determining retinal neuron identities
Interests: retinal development; stem cell-based human retinal organoids; neuroprotection mechanisms; viral mediated gene delivery and therapy
Retinal ganglion cells (RGCs) are the output neurons of the retina. RGC death is crucial in many retinal diseases leading to blindness, such as glaucoma, optic neuritis, diabetic retinopathy, pathological myopia, and optic nerve injury. Since the loss of RGCs results in the irreversible loss of vision and no effective treatment is available to date, effectively preventing RGC death or regenerating RGCs under disease conditions must be addressed in the research. However, the death of RGCs in these disease conditions involves multiple molecular and cellular mechanisms. In addition, numerous studies have demonstrated that RGCs present significant subtype-specific vulnerabilities to pathological insults. Therefore, the research requires rigorous efforts and a thorough understanding of distinct but interlinked processes, including the molecular mechanisms that regulate RGC differentiation and survival, genes that promote RGC regeneration, proteins or small molecules that prevent RGC death, and the mechanisms that control the integration of regenerated or transplanted RGCs into existing neuronal circuits. The research also requires the development of innovative techniques to activate intrinsic stem cells for RGC regeneration or to promote the ex vivo growth of RGCs for transplantation.
The aim of this Special Issue of Cells is to collate the latest high-quality articles written by researchers working in all areas related to the injury, degeneration, survival, and regeneration of vertebrate RGCs in a collection of original research articles, reviews, and communications. The scope will be comprehensive, including the genetic, molecular, anatomical, physiological, and pathophysiological mechanisms and signaling pathways that control RGC development, degeneration, and regeneration under normal and disease conditions.
Prof. Dr. Ning Tian
Dr. Lin Gan
Dr. Xian-Jie Yang
Dr. Yongling Zhu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- retinal ganglion cells
- RGC development
- RGC degeneration
- RGC and axonal regeneration
- molecular mechanism
- RGC survival
- signal transduction pathways
- RGC injury
- RGC transplantation
- retinal organoid
- optic neuropathy
- retinal circuits