Special Issue "The Role of Neural Stem/Progenitor Cells in Neurological Diseases"
Deadline for manuscript submissions: 31 October 2023 | Viewed by 2104
Interests: neuroscience; Alzhimer's diseases; Parkinson's diseases; senescence; cell biology; stem cells; extracellular vesicles; biomarker bioinformatics; statistics
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Neural stem progenitor cells (NSPCs), self-renewing multipotent cells, persist from embryogenesis and are capable of differentiation into neurons, astrocytes, and oligodendrocytes. Because their proliferation and differentiation are tightly controlled in brain development, the disturbance of NSPC biology is responsible for various neurological diseases, from developmental and psychiatric disorders to degenerative diseases and cancers in adults. In addition, NSPCs carefully develop cell therapies for diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s diseases, and the transplantations of NSPCs through different routes are performed in order to recover the pathophysiological deficits in the diseases. Since NSPCs can be generated from induced pluripotent stem cells, the cell applications are expanded to neural tissue engineering with a three-dimensional culture system and development of personalized neurotoxic tests and therapies, which help us find new interventions and understand the underlying mechanisms of neurological diseases. Both NSPCs themselves and the derivatives from the cells, including conditioned media, secreted factors, and extracellular vesicles, are under intensive investigation to understand the NSPC-mediated modulation of neuronal diseases. Because of their different roles in neurological disorders, diverse approaches of NSPC investigation are required for comprehending the nature of NSPCs.
This Special Issue aims to expand the current knowledge on the roles of NSPCs and their derivatives in neurological diseases from the pathological mechanism to the possible therapeutic mechanism, and from new applications to development of noble interventions.
We look forward to your contributions.
Dr. Jisook Moon
Manuscript Submission Information
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- neural stem/progenitor cells (NSPCs)
- neurological diseases
- neurodegenerative diseases
- pathophysiological mechanism
- NSPC derivatives
- conditioned media
- secreted factors
- extracellular vesicles
- therapeutic intervention