Special Issue "Cell Biology Research in Model Organism Drosophila"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 February 2024 | Viewed by 693
Interests: Drosophila melanogaster; Drosophila model; oncoprotein; cytokinesis
Special Issues, Collections and Topics in MDPI journals
Cell biology, as a fundamental branch of science, unravels the intricacies of cellular structure, function, and organization, thereby shaping our understanding of life itself. The model organism Drosophila melanogaster, commonly known as the fruit fly, has emerged as a powerful and versatile tool for probing into the mysteries of cell biology. With its well-characterized genetics, short life cycle, and conserved cellular processes, Drosophila offers unique advantages to investigate cellular mechanisms with unparalleled precision and efficiency.
This Special Issue seeks to showcase the latest advancements and breakthroughs in cell biology research utilizing Drosophila as a model organism. Our aim is to bring together researchers and experts from diverse disciplines, fostering collaboration and knowledge exchange, ultimately pushing the boundaries of our comprehension of cellular processes.
This Special Issue encompasses a wide array of topics within cell biology research, all centered around the invaluable contributions of Drosophila as a model organism. Topics of interest include, but are not limited to, the following:
- Cellular Signaling Pathways: Investigating the intricate signaling cascades that regulate cellular processes, such as cell growth, differentiation, and apoptosis, in the context of Drosophila model systems.
- Cellular Morphogenesis: Exploring the dynamic changes in cell shape and structure during development, tissue regeneration, and organogenesis in Drosophila, shedding light on fundamental processes that shape multicellular organisms.
- Cell Division and Cell Cycle Regulation: Unraveling the mechanisms governing cell cycle progression, chromosome segregation, and the regulation of cell division fidelity in Drosophila cells.
- Cellular Trafficking and Transport: Investigating the intricate networks of intracellular transport and vesicle trafficking, elucidating the mechanisms of cargo delivery and compartmentalization in Drosophila cells.
- Cellular Homeostasis and Stress Responses: Understanding how Drosophila cells maintain homeostasis and respond to various environmental stresses, providing insights into cellular adaptability and survival.
- Cellular Interactions and Communication: Studying cell–cell interactions and communication, including cell adhesion, synaptic transmission, and immune responses, in the context of Drosophila model systems.
We invite researchers, academics, and scientists with a keen interest in cell biology and Drosophila research to contribute either orignial research articles or reviews to this Special Issue. Through this collaborative effort, we aim to foster a vibrant and stimulating scientific environment, driving innovative discoveries, and further cementing Drosophila as an indispensable model organism for cell biology research.
We look forward to your valuable contributions.
Dr. Maria Grazia Giansanti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drosophila melanogaster
- model organism
- cell biology
- developmental biology
- molecular biology
- cell signaling
- cellular differentiation
- cell proliferation
- cell cycle
- cellular morphogenesis
- cell-cell communication
- stem cells
- organelle biology
- cell migration
- cell adhesion
- membrane trafficking
- intracellular transport
- genome stability
- cellular metabolism
- immunity in drosophila
- RNA biology
- protein folding
- functional genomics
- CRISPR/Cas9 in drosophila
- omics technologies
- disease models
- drug discovery
- genetic screens
- cellular stress responses
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Using Drosophila melanogaster to dissect the roles of the mTOR signaling pathway in cell growth.
Authors: Anna Frappaolo; Maria Grazia Giansanti
Affiliation: Affiliation 1, Istituto di Biologia e Patologia Molecolari del CNR, c/o Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy
Abstract: The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from nutritional status and growth factors. TOR is the catalytic subunit of two distinct functional multiprotein complexes termed 1 mTORC1 (mechanistic target of rapamycin complex 1) and mTORC2, which phosphorylate a different set of substrates and display different physiological functions. Dysregulation of TOR signaling has been involved in the development and progression of several disease states including cancer and diabetes. Here we highlight how genetic and biochemical studies in the model system Drosophila melanogaster have been crucial to identify the TORC1 and TORC2 signaling components and to dissect their function in cellular growth, in strict coordination with the insulin signaling. In addition, we review new findings that involve Drosophila Golgi phosphoprotein 3 in regulating organ growth via Rheb-mediated activation of TORC1 in line with an emerging role of the Golgi as a major hub for mTORC1 signaling.