Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 190

Special Issue Editors

E-Mail Website1 Website2
Guest Editor
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland
Interests: obesity; mesenchymal stem cells; insulin resistance; diabetes mellitus; cardiovascular diseases; adipocytes; skeletal muscle; metabolic syndrome; lipid metabolism; fatty acid handling proteins, cellular metabolism
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland
Interests: cellular physiology

Special Issue Information

Dear Colleagues,

The worldwide increase in the prevalence of obesity has raised the demand for new therapeutic strategies targeting the related chronic metabolic complications. Among different treatment options for obesity, mesenchymal stem cell (MSC) therapy attracts the most attention. The unique features of MSCs, including immunosuppressive and immunomodulatory properties, make them an ideal candidate for clinical applications. Numerous data have shown that MSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress. Nevertheless, the transplantation of mesenchymal stem cells is associated with certain risks; therefore, recently, much attention has been devoted to MSC derivatives, such as exosomes or conditioned media (CM), as therapeutic agents for the treatment of metabolic complications of obesity. MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.

This Special Issue aims to provide a comprehensive overview of the therapeutic potential of mesenchymal stem cells (MSCs) in the treatment of obesity-related metabolic complications such as type 2 diabetes mellitus (T2DM), insulin resistance (IR), hepatic steatosis, hepatic fibrosis, infertility, vascular disorders or systemic inflammation. Authors are invited to submit original articles, review articles or meta-analyses/systematic reviews with new insights into MSC-based therapy.

We look forward to your contributions.

Dr. Agnieszka Mikłosz
Dr. Bartłomiej Łukaszuk
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diabetes mellitus
  • dyslipidemia
  • insulin resistance
  • metabolic syndrome
  • mesenchymal stem cells
  • obesity

Published Papers

This special issue is now open for submission.
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