Special Issue "Ubiquitin and Ubiquitin-Like Proteins: From Molecular Mechanisms to Human Diseases"
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 3446
2. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
Interests: protein post-translational modification; ubiquitin; ubiquitin-like proteins; protein degradation; proteasome; autophagy; cardiomyopathy; heart failure
Recent advances in genome- and transcriptome-wide measurements at either single-cell levels or tissue levels have significantly improved our understanding of molecular mechanisms underlying tissue homeostasis and disease progression. However, increasing evidence has revealed a remarkable discordance between mRNA and protein levels in nearly all tested tissues, calling for more research attention on post-translational mechanisms controlling cellular processes and pathophysiological events. Ubiquitin and ubiquitin-like proteins are evolutionarily highly conserved small protein modifiers that can reversibly modify diverse cellular substrates via a similar E1-E2-E3 enzymatic cascade. Such modifications can conjugate one single or a chain of protein modifier moieties to target proteins. Conceptually, these modifications can have subtle or drastic effects on the protein targets’ stability, activity, intracellular distribution, and interaction with DNA and protein partners. Through either fine-tuning or significantly altering the protein's function, ubiquitin and ubiquitin-like protein-mediated modifications are emerging as novel mechanisms regulating a wide spectrum of cellular processes and biological events. In this Special Issue, we seek articles that enhance our understanding of how ubiquitin and ubiquitin-like proteins regulate protein function and impact health and disease. Original research articles or reviews centered on ubiquitin and ubiquitin-like proteins are of interest to this Special Issue.
Dr. Huabo Su
Dr. Md. Shenuarin Bhuiyan
Manuscript Submission Information
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- ubiquitin-like protein
- protein modification
- protein degradation