Extracellular Vesicles as Modulators of Cancer Initiation, Progression and Therapy Resistance—Series II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 271

Special Issue Editors

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Guest Editor
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
Interests: prostate cancer; melanoma; ovarian cancer; cancer biology; mechanisms of cancer cell death; cancer metastasis; cancer metabolism; cancer drug resistance; cancer stem cells; tumor microenvironment; extracellular vesicles
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Guest Editor
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
Interests: EVs in cancer drug resistance and therapy escape; mechanisms underlying EV uptake and cargo utilization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the successful publication of the first Special Issue of “Extracellular Vesicles as Modulators of Cancer Initiation, Progression and Therapy Resistance”, we are very pleased to launched the new edition, which is dedicated to highlighting the recent developments in this field.

Extracellular vesicles (EVs) are 50–1000 nm sized, membrane-bound particles released by both eukaryotic and prokaryotic cells and involved in cell-to-cell communication. They can be found in various body fluids, such as blood, urine and saliva, and transfer proteins, RNAs, miRNAs and lncRNAs from the originating cells to both neighboring and distant cells.

It is now widely accepted that EVs play a key role in different tumorigenic processes, including cancer proliferation, migration and angiogenesis, as well as tumor drug resistance. Moreover, they are implicated in the interactions between malignant and non-malignant cells in the tumor microenvironment, such as stromal and immune cells. Due to their ubiquitous presence in body fluids and their characteristic of often reflecting the molecular signature of the donor cell, they have recently emerged as promising biomarkers for cancer diagnosis and prognosis. Exciting therapeutic strategies aimed at exploiting EVs as biocompatible drug delivery platforms are also being explored.

This Special Issue focuses on the role of EVs in cancer development, metastasis and therapy resistance. Original papers and review articles on the following topics are welcome: (I) mechanisms of EVs’ release and uptake in cancer; (II) EV-mediated cross-talk between malignant and non-malignant cells in the tumor microenvironment; (III) EVs’ role in the emergence of cancer drug resistance; (IV) EVs as a source of biomarkers for cancer diagnosis and prognosis; (V) EVs as drug delivery vehicles for cancer treatment.

Dr. Fabrizio Fontana
Dr. Priya Samuel
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • extracellular vesicles
  • exosomes
  • microvesicles
  • tumor microenvironment
  • cancer drug resistance
  • cancer diagnosis
  • cancer prognosis
  • biomarkers
  • liquid biopsies
  • cancer therapy

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Published Papers

There is no accepted submissions to this special issue at this moment.
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