Computational Studies of Mutagenic Processes in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Informatics and Big Data".
Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 5330
Special Issue Editors
Interests: computational biology; cancer; systems biology; gene regulation; disease
Interests: molecular evolution; comparative genomics; phylogenetics; Markov chains; Bayesian networks; Monte Carlo methods; algorithms for random generation; approximate counting
Interests: biological data modeling; data mining; graph algorithmic and machine learning techniques; computational studies
Special Issue Information
Dear Colleagues,
Recent advances in the computational analysis of somatic mutations in cancer genomes provided a wealth of information on mutagenic processes in cancer. For example, there is a growing recognition that mutagenic processes can be studied through the lenses of mutational signatures: characteristic mutation patterns attributed to individual mutagens. Several computational approaches were recently developed for the identification of these patterns and to link them to specific causes. However, the etiology of many mutational patterns remains unknown or not fully understood.
It was also recognized that the mutation landscape of a cancer genome is the result of a complex interaction between DNA damage, DNA repair, and other processes in the cell such as replication stress. New computational methods and analyses began to uncover and model these dependencies.
This Special Issue will focus on recent advances in the computation analysis of mutational processes, including emerging computational methods and new insights obtained through computational approaches applied to large cancer datasets.
Dr. Teresa M. Przytycka
Dr. Damian Wójtowicz
Prof. Dr. Roded Sharan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- somatic mutations
- mutational signatures
- DNA damage
- DNA repair
- mutational processes and chromatin/DNA structure
- mutational processes and cancer evolution
- mutational processes and molecular pathways
- mutational processes and environment