Dear Colleagues,

Cervical cancer is the fourth most common cancer among women. The disease particularly disrupts the lives of women and their families in low- and middle-income countries [1], and in high-income countries women with a barrier to prevention, to early detection and to appropriate care [ref 2]. International efforts against cervical cancer are primarily focused on prevention by vaccination of HPV and screening for pre-malignant stages [3]. The reality is that most preventive strategies will be effective only in the distant future, 20 to 30 years from now, and they do not adequately reach the high-risk population who would benefit most. In underserved populations, the majority of patients present with locally advanced cervical cancer disease (LACC). Therefore, optimal management of women with LACC remains a major and difficult challenge.

In this forthcoming Special Issue, a motivated international team of experts from many medical disciplines will address a comprehensive scope of topics. Topics ranging from a description of the history, epidemiology and demography of patients with LACC, to clinical reviews and original papers on diagnosis, the role of radiotherapy and combined modality treatment, the role of surgery, particularly for nodal disease and for recurrent disease, and the promises of innovative drugs and therapeutic vaccination are all welcome. Considering the major burden of disease and its treatment, the management of late toxicity, and preservation of quality of life will be covered in separate chapters. Since social and economic determinants strongly determine the fate of women with LACC, we will pay special attention to social and economic issues, such as the organization and cost of care for women in low-, middle- and high-income countries.

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021:71:209–49. doi:10.3322/caac.21660.
2. Paper on SES and cervical cancer in Western countries.
3. WHO—World Health Organization. Cervical Cancer, 22 February 2022.

Prof. Dr. Lukas Stalpers
Dr. Constantijne H. Mom
Dr. Maaike A. Van der Aa
Guest Editors

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