Special Issue "New Insights into Oropharyngeal Cancer"
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 4002
Interests: head and neck cancer; cell cycle; drug resistance; stemness; EMT; surgery; chemoradiotherapy
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Oropharyngeal cancer has recently attracted the attention of more researchers in the field of head and neck malignancy. Particularly, HPV-associated oropharyngeal squamous cell carcinoma (SCC), which is increasingly common in economically developed countries, shows high sensitivity to chemoradiation. It is clearly biologically different from conventional smoking-related and drinking-related oropharyngeal SCC. Immunostaining of p16 as a marker for HPV-associated oropharyngeal SCC has been adopted in the 8th edition of the UICC stage classification. As a result, clinical studies are underway in many countries to reduce the intensity of chemoradiation therapy for HPV-associated oropharyngeal SCC. Although it has already been demonstrated that some subgroups of HPV-associated oropharyngeal SCC have poor prognosis, appropriate treatment for these subgroups has not yet been determined. Additionally, many scientific issues remain to be clarified, such as the biological mechanisms of the tumor microenvironment, including immuno-oncology. Novel findings obtained from clinical study are expected to be crucially important for indications of surgery or chemoradiotherapy for both HPV-related and HPV-unrelated oropharyngeal cancer. Consequently, it is necessary to accumulate new knowledge related to unresolved oropharyngeal cancer. The reports presented in this Special Issue are expected to enhance our understanding of the biological characteristics of oropharyngeal SCC and to promote future clinical applications and breakthroughs.
Dr. Narita Norihiko
Dr. Hideki Matsumoto
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- oropharyngeal squamous cell carcinoma
- chemoradiation therapy
- clinical trial
- molecular biological research
- translational research
- recurrence and metastasis
- drug resistance