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Special Issue "Iron and Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 7521
Special Issue Editors
Interests: oxidative stress; iron metabolism; mesothelioma
Interests: iron metabolism; mitochondria; ozidative stress
Special Issue Information
Iron is an essential element for all organisms. Iron-containing proteins play critical roles in cellular functions. The biological importance of iron is largely attributable to its chemical properties as a transitional metal. However, an excess of “free” reactive iron damages the macromolecular components of cells and cellular DNA through the production of harmful free radicals. These properties are closely associated with carcinogenesis. For instance, hepatocellular carcinoma, malignant mesothelioma, and ovarian clear cell carcinoma have been shown to develop in relation to excess iron and/or oxidative stress caused by free radicals. In the last decade, accumulating evidence regarding molecules regulating iron metabolism or iron-related cell death programmes such as ferroptosis has shed light on the relationship between excess iron and carcinogenesis. Furthermore, iron depletion by chelating is shown to be a promising therapeutic option in several cancers.
This Special Issue will highlight the current knowledge on iron- and metal-related biology for understanding pathogenesis-based therapy and prophylaxis.
Dr. Yasumasa Okazaki
Prof. Dr. Keisuke Hino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.