Special Issue "Genetic and Epigenetic Regulation of Tissue Homeostasis in Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4575
Interests: cancer; cell signaling; epigenetics; tissue homeostasis; therapeutic response
Interests: genome integrity; epigenetic regulation; gene expression; translation; viruses; molecular virology; viruses’ evolution
Special Issues, Collections and Topics in MDPI journals
Special Issue in Life: Ecology, Evolution and Epidemiology of Coronaviruses
Topical Collection in Cancers: Tumor Evolution: Progression, Metastasis and Therapeutic Response
Special Issue in Cancers: Clonal Evolution in Cancer
Epithelial tissues represent the dynamic barriers between the external environment and internal surfaces of our bodies. This vital function requires extended networks of cell–cell and cell–extracellular matrix interactions which stabilize tissues but also facilitate communication with the microenvironment. To support tissue homeostasis and injury-induced repair, a hierarchical cellular architecture, with tissue-specific stem/progenitor cells, differentiating into a whole range of specialized cells is maintained and tightly regulated. These tissue homeostasis processes are driven and defined by specific transcriptional and epigenetic landscapes that determine the cellular identity within tissue. As a result, epithelial integrity and homeostasis are safeguarded by a finely tuned balance between proliferation and differentiation. Similar principles apply to nonepithelial tissues, including the nervous system, the hemopoietic system and endothelial and stromal tissues.
Early stages of carcinogenesis are characterized by genomic and epigenetic alterations that lead to tissue disorganization, as poorly differentiated transformed cells exhibit a marked loss of traits associated with epithelial integrity.
For this Special Issue of Cancers, we invite authors to submit contributions that provide novel findings in the field of cancer progression in epithelia. In particular (though not limited to), insights in developmental pathways, epigenetic and transcriptional changes, tissue repair and regeneration, extracellular matrix–epithelial cell communication, with respect to loss of epithelial integrity during early phases of carcinogenesis, are of great interest. Reviews that highlight new findings in the above areas are also welcome.
Dr. Apostolos Klinakis
Dr. Theodoros Rampias
Dr. Panagiotis Karakaidos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- stem cells
- tissue integrity
- tissue homeostasis
- tissue repair
- tissue microenvironment
- signaling imbalance
- developmental pathways in cancer
- cancer stem cells
- tumor microenvironment