Metronomic Chemotherapy in Cancer Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 69

Special Issue Editor

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Guest Editor
Department of Oncology, Jagiellonian University Medical College, 31-007 Cracow, Poland
Interests: metronomic chemotherapy; geriatric oncology; combined treatment modalities; novel therapeutic targets; breast cancer; ovarian cancer; prostate cancer; RCC; urothelial cancer
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Special Issue Information

Dear Colleague,

Despite profound progress in cancer treatment and the development of many novel molecularly targeted agents, chemotherapy remains the backbone and most often used form of systemic therapy for oncological malignancies. With the advent of targeted chemotherapy, which is based on antibody–drug conjugates, there is discussion regarding if and for how long classical chemotherapy will remain in the armamentarium of medical oncologists. Nevertheless, classical chemotherapy is still routinely used in both curative and palliative settings, but the way oncologists use this therapeutic tool has significantly evolved over the last decades. One essential step toward improving the safety and efficacy of chemotherapy, especially when administered in a palliative, long-term setting, is to administer cytotoxic drugs in a metronomic fashion. Metronomic chemotherapy represents a unique chemotherapeutic treatment modality that utilizes single- or multi-agent regimens, administered in short or ultra-short intervals. This strategy, owing to its excellent safety profile and multidirectional antitumor activity (inhibiting tumor cell proliferation, suppressing tumor-induced angiogenesis, and reversing immunosuppression) represents a unique but broadly unappreciated systemic treatment strategy. Moreover, metronomic chemotherapy may represent a unique therapeutic partner for many targeted agents (kinase inhibitors, immune checkpoint inhibitors, endocrine agents), and this concept is being evaluated in many recently initiated clinical studies. The focus of this Special Issue is includes the following: (a) describe the mechanisms of the action of metronomic chemotherapy; (b) present the potential of metronomic chemotherapy in the treatment of various cancers; (c) discuss the role of metronomic chemotherapy as a partner for novel strategies, combining it with molecularly targeted agents and immunotherapies; (d) underscore the role of metronomic chemotherapy in low- and middle-income countries, where, in many cases, it may offer an alternative to the novel, financially unavailable cancer treatments.

Dr. Piotr J. Wysocki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metronomic chemotherapy
  • solid tumors
  • breast cancer
  • gynecological cancer
  • genitourinary cancers
  • gastrointestinal cancers
  • lung cancer
  • combined cancer treatment

Published Papers

This special issue is now open for submission.
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