Special Issue "Histology and Pathology of Pancreatic Cancer"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 16 January 2024 | Viewed by 207

Special Issue Editors

Dr. Jiaqi Shi
E-Mail Website
Guest Editor
Department of Pathology & Clinical Labs, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Interests: pancreas pathology; pancreatic cancer biology; tumor microenvironment; epigenetic regulation
Dr. Olca Basturk
E-Mail Website
Guest Editor
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Interests: pancreaticobiliary diseases; pancreas and gallbladder neoplasms

Special Issue Information

Dear Colleagues,

Pancreatic cancer is a heterogeneous group of malignant epithelial neoplasms arising from the pancreas. Pancreatic ductal adenocarcinoma (PDA) is the most common type of pancreatic cancer and is the third leading cause of cancer death in the U.S., with a dismal 12% five-year survival rate. There are many recent developments in molecular classifications, candidate targetable molecular alterations, and the important role of tumor microenvironment in pancreatic cancer. Specifically, we learn that PDAs can be molecularly classified into classical and basal subtypes, with the latter subtype carrying a much worse prognosis and less treatment response. Identifying mismatch repair protein deficient PDAs, BRCA1/2 or PALB2-mutated PDAs, and PDAs with NTRK fusion provided new biomarkers to guide therapy. Additionally, classifications of pancreatic neuroendocrine neoplasms and cystic intraductal neoplasms have been recently updated due to new molecular and clinical findings.

It is crucial to understand the interaction between PDA cells and their surroundings. Increasing evidence supports the importance of the tumor microenvironment in PDA progression and immune evasion. PDA cells interact with heterogenous cancer-associated fibroblasts, immune cells, adipocytes, endothelial, dendritic, and other cells in the tumor microenvironment to facilitate tumor growth. Cytokines, metabolites, and other signaling molecules in the tumor microenvironment also promote tumor development and maintenance.

This Special Issue will spotlight the latest advances in the histology and pathology of pancreatic cancer, focusing on the new classifications, prognosis and treatment biomarkers, and the role of the tumor microenvironment

Dr. Jiaqi Shi
Dr. Olca Basturk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pancreatic cancer
  • pathology
  • classification
  • molecular mechanisms
  • tumor microenvironment

Published Papers

This special issue is now open for submission.
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