Immunotherapy Approaches in Breast Cancer Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 126

Special Issue Editors

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Guest Editor
1. Department of Internal Medicine, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
2. Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
Interests: breast cancer; epigenetics; cancer pharmacology; immuno-oncology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40536, USA
Interests: breast cancer; obesity and immunoregulation; fatty acid binding proteins; cancer immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Breast cancer (BC) is the second leading cause of female cancer death in the U.S. BC is heterogeneous in nature and the different subtypes of BC show considerable variability in clinical behavior, histologic features, and biological properties. Genetic and/or epigenetic defects in BC cells lead to the development of immunosuppressive environment and tumor escape from immune surveillance.

Recently, immunotherapy has been emerging as an exciting new treatment option for BC, especially for triple-negative breast cancer (TNBC). While TNBC is more likely to respond to immunotherapy, the overall response rate is still low. Thus, developing more efficacious antitumor immune drugs and rational combination solutions is critical for improving the clinical outcomes of immunotherapy in BC. BC is historically regarded as an immunologically quiescent (cold) tumor. We are facing many challenging issues in BC immunotherapy. We need to better understand how diverse tumor microenvironment contributes to immunotherapy resistance and identify unique biomarkers in order to optimize the combination of immunotherapy with other therapies.

The goal of this Special Issue is to bring basic scientists and clinical investigators together to explore problems and challenges regarding BC immunotherapy. Special considerations would be given to findings of new mechanisms of tumor immune microenvironment, immune evasion, immune cell functions, immunotherapy resistance, and novel combination strategies in BC. We expect that this topic would provide new insight into BC biology and facilitate innovative approaches to improve the outcomes of immunotherapy in breast cancer.

Dr. Yi Huang
Prof. Dr. Bing Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • breast cancer progression
  • immunotherapy
  • combination therapy
  • drug discovery
  • antitumor immunity
  • tumor immune microenvironment
  • biomarkers and clinical trials

Published Papers

This special issue is now open for submission.
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