Special Issue "Pathology and Genetics of Glioblastoma"
Deadline for manuscript submissions: closed (10 November 2023) | Viewed by 930
Interests: meningiomas; glioma; glioblastoma; ganglioglioma
Special Issues, Collections and Topics in MDPI journals
Glioblastomas (GBMs) are the most common primary brain tumors of adults. They show aggressive behavior and a poor prognosis, and despite intensive research on molecular targets, there is still no curative therapy. In the current 2021 WHO Classification of CNS tumors, novel genetic and epigenetic aspects are highlighted, contributing to GBM initiation and progression.
The most common genetic alterations in GBMs are TERT mutations as well as EGFR amplifications and CDKN2A/B deletions. Furthermore, GBMs show aberrant DNA-methylation landscapes altering numerous biological pathways. This leads to an intimate relationship of GBM cells with the microenvironment, supporting tumor growth. Therefore, it is necessary to understand genetic and epigenetic mechanisms occurring in GBMs in order develop advanced therapy strategies.
This Special Issue of Cancers invites contributions (original research articles and reviews) that highlight our enhanced understanding of the genomic and epigenomic landscape of GBMs to better understand the pathology underlying glioblastomas, opening up new ways in glioblastoma therapy.
We look forward to receiving your contributions.
Dr. Theo Kraus
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.