Early Onset Colorectal Cancer: Epidemiology, Etiology, Mechanisms and Outcomes (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1698

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Guest Editor
Department of Medicine, Biochemistry, Oncology, Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Interests: energy balance; obesity cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous one, "Early Onset Colorectal Cancer: Epidemiology and Etiology" (https://www.mdpi.com/journal/cancers/special_issues/EOCRC).

Early Onset Colorectal Cancer (EO-CRC), occurring in individuals younger than 50 years of age, has been noted to be increasing in incidence in the U.S. and many countries worldwide. The emergence of EO-CRC is particularly notable, as the overall incidence of CRC is decreasing, presumably due to widespread screening which results in the early detection and treatment of premalignant lesions. The apparent shift in the occurrence of CRC to EO-CRC presents multiple challenges to our understanding and approach to CRC carcinogenesis. It is especially concerning because EO-CRC is reported to have a worse prognosis than CRC, and also because it is more likely to impact individuals in their prime productive years. The prognosis of EO-CRC may be associated with distinct anatomical distribution and/or molecular phenotypes. In addition, EO-CRC has been noted among unique populations where it may be related to genetics or exposure, and/or it may be associated with disparities in care. Epidemiologic and molecular studies suggest family history, obesity, maternal obesity, antibiotic use and specific dietary components are contributors.

As a result of the emerging importance of EO-CRC, the first Special Issue of Cancers has been completed. We are now pleased to invite you to submit an article for this second Special Issue of Cancers, which is focused on improving our understanding of epidemiologic, etiologic and mechanistic factors as well as outcomes that may contribute to the early detection, prevention, control and/or therapy of EO-CRC. In this second Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Nathan A. Berger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Early Onset-Colorectal Cancer (EO-CRC)
  • EO-CRC—Molecular Genetics and Epigenetics
  • EO-CRC—Animal Models
  • EO-CRC—Epidemiology
  • EO-CRC—Anatomical Distribution
  • EO-CRC—Obesity
  • EO-CRC—Unique Populations
  • EO-CRC—Geographic Distribution
  • EO-CRC—Dietary Components

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Published Papers (1 paper)

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Review

14 pages, 709 KiB  
Review
The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
by Rui Dai, Bridget N. Kelly, Amarachi Ike, David Berger, Andrew Chan, David A. Drew, David Ljungman, David Mutiibwa, Rocco Ricciardi, Gerald Tumusiime and James C. Cusack
Cancers 2024, 16(3), 676; https://doi.org/10.3390/cancers16030676 - 05 Feb 2024
Cited by 3 | Viewed by 1457
Abstract
Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. [...] Read more.
Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. This review provides an overview of current research and putative mechanisms behind the rising incidence of colorectal cancer in the younger population, with insight into future interventions that may prevent or reverse the rate of early-onset colorectal carcinoma. Full article
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